Description
Drug Metabolism in Diseases: Leveraging Drug Metabolism and Disposition in Precision Medicine and Therapeutic Development, Second Edition provides essential knowledge for pharmaceutical scientists and biologists to understand the interplay between diseases and physiological conditions, impacting drug metabolism and its implications in personalized treatment. Expanded with six new chapters since the first edition, this updated book covers the latest scientific findings. Other important points include the book's comprehensive reference on mutual effects between drug metabolism and diseases, implications in precision medicine, and therapeutic development. Pharmaceutical scientists, drug metabolism researchers, and research physicians will benefit from the expert insights provided.- Provides a comprehensive overview of how diseases and physiological conditions impact drug metabolism and disposition- Presents insights into leveraging drug metabolizing enzymes and transporters as therapeutic targets- Updates across all content to provide a current and updated view on this rapidly evolving research topic
Table of Contents
1. Introduction of drug metabolism and overview of disease effects on drug metabolism2. Regulation of drug metabolizing enzymes by inflammation3. Regulation of drug transporters by inflammation4. Drug metabolism in metabolic syndrome5. Drug metabolism in transplant patients6. Drug metabolism in kidney diseases7. Drug and fatty acid cytochrome P450 metabolism in critical care8. Drug metabolism in patients of cardiovascular disease9. Drug metabolism In pediatric patients10. Drug metabolism in geriatric patients11. Drug metabolism in pregnancy12. Developmental regulation of drug metabolism and disposition13. Effect of gut microbiota on xenobiotic and endobiotic metabolism14. Regulation of expression of drug-metabolizing enzymes by oncogenic signaling pathways15. Drug metabolism in HIV patients16. Estrogen sulfotransferase in mediating disease-drug interactions, a case study17. Xenobiotic receptors in the crosstalk between drug metabolism and energy metabolism
