Ｔ細胞代謝と癌免疫治療 T Cell Metabolism and Cancer Immunotherapy

著者名：Song PhD, Jianxun (EDT)

Academic Press（2024/11/27発売）

• 言語：ENG
• ISBN：9780443138270
• eISBN：9780443138287

Description

T Cell Metabolism and Cancer Immunotherapy investigates the cellular regulation of T-cell immunity and tolerance. Most effort is being expended to develop and optimize strategies for utilizing highly reactive T lymphocytes for cell-based therapies. Because of the plasticity and potentially unlimited capacity for self-renewal, stem cell-derived T lymphocytes have great potential in the treatment of diseases including cancer. Despite great advancement in immunotherapy such as adoptive T cell transfer-based regimen, the clinical outcomes remain less satisfactory due to a variety of factors that lessen its therapeutic efficacy.  By determining the role and importance of T cell metabolism in the regulation of T lymphocytes that are related to the development and managements of aberrant immunity, T Cell Metabolism and Cancer Immunotherapy designs and develops novel and more effective strategies for improving regimens for patients with aberrant immunity.Within ten chapters the content not only reveals targets of T cell metabolism as critical determinants of immune regulation, but also uncovers unique therapeutic opportunities to improve immunotherapy through targeting T cell metabolism. This fills a significant gap in the knowledge of scientists working in the field of onco-immunology/immunotherapy, and students learning about T cells, metabolism, immunomodulation, and immunotherapy- Provides a summary of the current state-of-the-art, creating a valuable foundation for both established researchers and newcomers/students in the field in cancer immunotherapies- Focuses on the investigation of cellular regulation of T-cell immunity and tolerance- Defines the precise role and mechanism of T cell metabolism in modulating T cells and T cell-mediated immunity

Table of Contents

1. Modulating T cell metabolism to improve T cell therapy2. Links between the DNA damage response and immune response in cancer3. Improving adoptive T cell therapy by positive conversion of negative signaling4. TGF-β in tumor microenvironment, metabolism, and immunotherapy5. Targeting Immunometabolism to Improve Cancer Therapies6. TCR-T Cells for Cancer Immunotherapy7. The Combination of Local Treatment and Immunotherapy8. T cell metabolism and cancer immunotherapy9. Exploring the Interplay of Kinases and Transcription Factors in Immunometabolism10. Targeting Engineered Bacteria to Improve Cancer Immunotherapy11. Salmonella: A Bacterial Warrior in Cancer Immunotherapy12. Oncolytic Virus for Cancer Immunotherapy13. Advances in Immunotherapy for Colorectal Cancer