Description
Conn's Handbook of Models for Human Aging, Second Edition, presents key aspects of biology, nutrition, factors affecting lifespan, methods of age determination, use in research and the disadvantages/advantages of use. Using a multidisciplinary approach, this updated edition is designed as the only comprehensive, current work that covers the diversity in aging models. Chapters on comparative models explore age-related diseases, including Alzheimer's, joint disease, cataracts, cancer and obesity. Also included are new tricks and approaches not available in primary publications. This must-have handbook is an indispensable resource for researchers interested in the mechanisms of aging, gerontologists, health professionals, allied health practitioners and students.- Combines both the methods of study for human aging and animal models- Provides a historical overview and discussion of model availability, key methods and ethical issues- Contains over 200 full color illustrations
Table of Contents
I. Aging in Humans1. Werner Syndrome as a model of human aging2. Premature aging syndrome3. Models, Definitions, and Criteria of Frailty4. Immunological methods and the concept of inflamm-aging in the study of human aging5. Vulnerability and Experiential Health in Old Age – a qualitative perspective6. Body composition analysis in older adults7. Using Computational Models to Study Aging 8. A framework for uncovering the roles of calories and macronutrients in health and aging9. Female Reproductive Aging: From Consequences to Mechanisms, Markers, and Treatments10. Adrenopause11. What sets Iceland apart in understanding human agingII. Animal models: Vertebrates 12. Reproductive Tract Lesions in Aged Chimpanzees13. Age-related changes to the bony structure and musculature of the shoulder in a nonhuman primate model14. The dog as a model for aging research15. Dogs as a Spontaneous Model for Early Alzheimer's Disease16. Determining cause of death and contributing causes of death in rodent aging studies17. Rat Models of Cognitive Aging18. Life Extension in Dwarf Mice19. Extension of Lifespan in Laboratory Mice20. Development and Validation of ECG analysis algorithm in mice21. Old mouse lemur: behavior, cognition and neuropathology22. Birds as models for the biology of aging and aging-related disease: an update23. Telomeres and Telomerase in Birds: Measuring Health, Environmental Stress and Longevity24. Zebrafish model for investigating the integrated control of reproduction25. Modelling aging and age-associated pathology in zebrafish26. The use of mature zebrafish (Danio rerio) as a model for human aging and disease27. Piscine polemics; Small tropical fish species as models for aging research28. The short-lived African turquoise killifish (Nothobranchius furzeri): a new model system for research on agingIII. Cellular models and invertebrates29. A Budding Topic: Modeling Aging and Longevity in Yeast30. The Budding and Fission Yeast Model Systems for Aging Biology: Rapid Advancement with New Technologies31. Podospora anserina: a filamentous fungus with a strong mitochondrial etiology of aging32. Invertebrates as model organisms for research on aging biology33. Invertebrate models for the study of the effects of age on neurotransmitter release34. Impact of Chronic Exercise on Invertebrate Functional Aging35. The virtues and challenges of multidimensional analyses of whole brains during aging with single cell resolution36. Rotifers as a Model for the Biology of Aging37. The Potential of Comparative Biology to Reveal Mechanisms of Aging in Rotifers38. Hydra, a model system for deciphering the mechanisms of aging and resistance to aging39. Regeneration and Aging in The Tunicate Ciona intestinalis 40. Honeybee Workers as Models of AgingIV. Disease models41. Approaches to the Assessment of Frailty in Animal Models42. Genotype and sex differences in life expectancy in transgenic AD mice43. Animal models of vascular cognitive impairment and dementia44. Alzheimer's Dementia Drug Discovery: Targeting Synaptic Glutamate Uptake45. A Transgenic Monkey Model of Huntington's Disease46. Parkinson's Disease in Humans and in Non-Human Primate Aging and Neurotoxin Models47. Genetic Models of Parkinson's Disease and Their Study in Non-Human Primates48. Impact of the Aged Brain Environment on Gene Therapy for Parkinson's Disease49. Cell Therapy for Parkinson's Disease50. Genetics of progeria and aging51. Progeria mouse models52. Models of Hypertension in Aging53. Osteoporosis and Cardiovascular Disease in the Elderly54. The role of the tumor microenvironment in pancreatic ductal adenocarcinoma and preclinical models to study itV. Organ systems55. Alopecia56. Experimental Models of human skin aging57. Muscle deconditioning and aging: experimental models58. Models of Immune Aging59. Sex and the aging immune system60. Rodent Models of Ovarian Failure61. Role of Sex and Aging in Mucosal Health62.
