Description
First developed as an accessible abridgement of the successful Handbook of Stem Cells, Essentials of Stem Cell Biology serves the needs of the evolving population of scientists, researchers, practitioners and students that are embracing the latest advances in stem cells. Representing the combined effort of seven editors and more than 200 scholars and scientists whose pioneering work has defined our understanding of stem cells, this book combines the prerequisites for a general understanding of adult and embryonic stem cells with a presentation by the world's experts of the latest research information about specific organ systems. From basic biology/mechanisms, early development, ectoderm, mesoderm, endoderm, methods to application of stem cells to specific human diseases, regulation and ethics, and patient perspectives, no topic in the field of stem cells is left uncovered.- Selected for inclusion in Doody's Core Titles 2013, an essential collection development tool for health sciences libraries- Contributions by Nobel Laureates and leading international investigators- Includes two entirely new chapters devoted exclusively to induced pluripotent stem (iPS) cells written by the scientists who made the breakthrough- Edited by a world-renowned author and researcher to present a complete story of stem cells in research, in application, and as the subject of political debate- Presented in full color with glossary, highlighted terms, and bibliographic entries replacing references
Table of Contents
FOREWORDWhy Stem Cell Research?A New Path ?{ Induced Pluripotent Stem Cells Embryonic Stem Cells Versus Adult Stem Cells'Stemness': Definitions, Criteria and StandardsPART ONEINTRODUCTION TO STEM CELLS 1. Present Perspective and Future Challenges 2. Embryonic Stem Cells in Perspective 3. The Development of Epithelial Stem Cell Concepts4. The Advent of Direct Reprogramming 5. Clinical Translation of Stem CellsPART TWOBASIC BIOLOGY/MECHANISMS6. Molecular Basis of Pluripotency 7. Stem Cell Niches8. Mechanisms of Stem Cell Self-Renewal 9. Cell Cycle Regulators in Stem Cells 10. Epigenetic Mechanisms of Cellular Memory11. Cell Fusion and the Differentiated State12. How Cells Change Their PhenotypePART THREETISSUE AND ORGAN DEVELOPMENT13. Differentiation in Early Development 14. Primordial Germ Cells in Mouse and Human 15. Stem Cells in Extraembryonic Lineages 16. Amniotic Fluid Derived Pluripotent Cells17. Cord Blood Stem Cells18. Neurogenesis in the Vertebrate Embryo19. The Nervous System20. Neuronal Progenitors in the Adult Brain21. Sensory Epithelium of the Eye and Ear22. Epithelial Skin Stem Cells 23. The Ontogeny of the Hematopoietic System 24. Hematopoietic Stem Cells 25. Red Blood Cells26. Cell Differentiation in the Skeleton27. Vascular Progenitor Cells28. Multipotent Adult Progenitor Cells29. Mesenchymal Stem Cells30. Skeletal Muscle Stem Cells31. Stem Cells and the Regenerating Heart32. Potential of ES Cell Differentiation Culture for Vascular Biology 33. Cell Lineages and Stem Cells in the Kidney34. Adult Liver Stem Cells35. Pancreatic Stem Cells36. Stem Cells in the Gastrointestinal Tract 37. Stem Cells in the Lung PART FOURMETHODS38. Generation of Induced Pluripotent Stem Cells 39. Characteristics and Characterization of Pluripotent Stem Cells 40. Isolation and Maintenance of Murine Embryonic Stem Cells41. Isolation, Characterization, and Maintenance of Primate ES Cells 42. Approaches for Derivation and Maintenance of Human ES cells: Detailed Procedures and Alternatives43. Derivation and Differentiation of Human EG Cells44. Growth Factors & the Serum-Free Culture of Human Pluripotent Stem Cells 45. Feeder-Free Culture46. Genetic Manipulation of Human Embryonic Stem Cells47. Homologous Recombination in Human Embryonic Stem Cells48. Surface Antigen Markers 49. Lineage Marking50. Genomic Reprogramming51. Isolation and Characterization of Hematopoietic Stem Cells52. Microarray Analysis of Stem Cells and Differentiation 53. Zebrafish and Stem Cell Research PART FIVEAPPLICATIONS54. Cancer Stem Cells55. Neural Stem Cells: Therapeutic Applications in Neurodegenerative Diseases56. Spinal Cord Injury57. Use of Embryonic Stem Cells to Treat Heart Disease58. Insulin-Producing Cells Derived from Stem Cells: A Potential Treatment for Diabetes59. Burns and Skin Ulcers 978-0-12-370465-860. Stem Cells and Heart Disease61. Stem Cells for the Treatment of Muscular Dystropy62. Skin Regeneration63. Orthopaedic Applications of Stem Cells64. Embryonic Stem Cells in Tissue Engineering65. Adult Stem Cells in Tissue Engineering66. Stem Cell Gene TherapyPART SIXREGULATION AND ETHICS67. Ethical Considerations 68. Religious Considerations69. Regulatory Considerations70. It¡¦s Not About Curiosity, It¡¦s About CuresEpilogue: Concluding Statement
