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Description
Advances in Radiation Biology, Volume 9, provides an overview of the state of knowledge in radiation biology. The book contains nine chapters and begins with a study on the ways in which physical and chemical agents might trigger "regulatory dysfunction" and how these agents might interact with each other. This is followed by separate chapters on the mechanisms underlying changes in vascular function after doses of radiation in the therapeutic range and their role in the development of late effects in normal tissues; the future of hypoxic cell sensitizers in the clinical setting; DNA strand break formation by ionizing radiation; and major pathways which result in radiation-induced loss of cellular proliferative capacity. Subsequent chapters deal with the solid-state radiation chemistry of DNA; radiosensitivity of proliferating mammalian cells; the use of microwave/radiofrequency energy cancer treatment; and the decline of basic radiobiology.
Table of Contents
ContributorsContents of Other VolumesThe Role of Radiation and Chemicals in the Induction of Mutations and Epigenetic Changes during Carcinogenesis I. Introduction II. General Conceptual Overview III. Mutations and Carcinogenesis IV. An Integrative Theory of Carcinogenesis V. Summary ReferencesRadiation-Induced Vascular Injury and Its Relation to Late Effects in Normal Tissues I. Introduction II. Morphological Changes III. Functional Changes IV. Mechanisms Underlying Changes in Vascular Function V. Response of Endothelial Cells VI. The Role of Vascular Damage in Late Effects VII. Summary ReferencesEvaluation of Nitroheterocyclic Radiosensitizers Using Spheroids I. Introduction II. Sensitization of Spheroids III. Cytotoxicity of Nitroheterocycles IV. Applied Therapy V. Other Effects of Nitroheterocycles VI. Conclusions and Future Directions ReferencesRadiation-Induced Strand Breaks in DNA: Chemical and Enzymatic Analysis of End Groups and Mechanistic Aspects I. Introduction II. Frequency of DNA Strand Breaks after Ionizing Radiation III. Enzymatic End Group Analysis in Irradiated DNA IV. Chemical Analysis of Damage to the Sugar Moiety of Irradiated DNA V. Mechanism of DNA Strand Break Formation by Ionizing Radiation Caused by Alterations of the Sugar Moiety VI. Summary ReferencesRadiation-Induced Events and Their Time Scale in Mammalian Cells I. Introduction II. Models III. Physical and Physicochemical Processes IV. Chemical Processes V. Biological Processes VI. Implications ReferencesSolid-State Radiation Chemistry of DNA: The Bases I. Radiation Biology, DNA, and the Solid State II. Evaluation of Free-Radical Assignments III. Free-Radical Events Induced by Ionizing Radiation IV. Notation V. Pyrimidines VI. Purines VII. Base Complexes VIII. DNA IX. Closing Comments ReferencesIntrinsic Radiosensitivity of Proliferating Mammalian Cells I. Introduction II. Radiation Target(s) III. Factors Determining Intrinsic Cellular Radiosensitivity IV. Concluding Remarks ReferencesFactors Governing the Use of Microwave/Radiofrequency Energies in Cancer Therapy I. Introduction II. Physical and Biophysical Principles III. The Physiology of Temperature Regulation IV. Rate of Microwave/Radiofrequency Energy Absorption in Living Systems V. Electromagnetic Energy Absorbed Dose in Humans VI. Specific Thermal Lesions VII. Whole-Body Hyperthermia VIII. Local Hyperthermia IX. Engineering Considerations X. Electromagnetic Field Measuring Instruments and Probes (Dosimetry) XI. Problems and Perspectives ReferencesThat Was the Basic Radiobiology That Was: A Selected Bibliography and Some Comments I. Introduction II. The Biophysical/Physicochemical Approach III. Mathematical Models IV. The Molecular-Biological/Biochemical Approach V. Basic or Applied Research in Radiobiology VI. Bibliographic Data on Radiobiology VII. Textbooks VIII. Monographs [M] IX. Reviews [R] X. Summary and Conclusions General References [G]Index
