基本説明
Completely revised to reflect the developments in this fast-changing field, this new edition features 35 % new content. The increase in biopharmaceutical substances is reflected by new and revised chapters on different modifications of continuous chromatography as well as ion-exchange chromatography and other separation principles widely used in biochromatography.
Full Description
Completely revised and substantially extended to reflect the developments in this fast-changing field. It retains the interdisciplinary approach that elegantly combines the chemistry and engineering involved to describe the conception and improvement of chromatographic processes. It also covers recent advances in preparative chromatographic processes for the separation of "smaller" molecules using standard laboratory equipment as well as the detailed conception of industrial chemical plants. The increase in biopharmaceutical substances is reflected by new and revised chapters on different modifications of continuous chromatography as well as ion-exchange chromatography and other separation principles widely used in biochromatography. Following an introductory section on the history of chromatography, the current state of research and the design of chromatographic processes, the book goes on to define the general terminology. There then follow sections on stationary phases, selection of chromatographic systems and process concepts. A completely new chapter deals with engineering and operation of chromatographic equipment.
Final chapters on modeling and determination of model parameters as well as model based design, optimization and control of preparative chromatographic processes allow for optimal selection of chromatographic processes. Essential for chemists and chemical engineers in the chemical, pharmaceutical, and food industries.
Contents
Preface INTRODUCTION On the Development of Chromatography Focus of the Book Recommendation to read this Book FUNDAMENTALS AND GENERAL TERMINOLOGY Principles of Adsorption Chromatography Basic Effects and Chromatographic Definitions Fluid Dynamics Mass Transfer Phenomena Equilibrium Thermodynamics Thermodynamic Effects on Mass Separation STATIONARY PHASES AND CHROMATOGRAPHIC SYSTEMS Column Packings Selection of Chromatographic Systems CHROMATOGRAPHY EQUIPMENT: ENGINEERING AND OPERATION Introduction Engineering and Operational Challenges Chromatography Columns Market Chromatography Systems Market Process Control Packing Methods Process Troubleshooting Disposable Technology for Bio-Separations PROCESS CONCEPTS Discontinuous Processes Continuous Processes Choice of Process Concepts MODELING AND MODEL PARAMETERS Introduction Models for Single Chromatographic Columns Modeling HPLC plants Calculations Methods Parameter Determination Experimental Validation of Column Models MODEL BASED DESIGN, OPTIMIZATION AND CONTROL Basic Principles and Definitions Batch Chromatography Recycling Chromatography Conventional Isocratic SMB Chromatography Isocratic SMB Chromatography under Variable Operating Parameters Gradient SMB Chromatography Multicolumn Systems for Bioseparations Chromatographic SMB Reactors Advanced Process Control APPENDIX B Data of Test Systems
