Description
Endothelium and Cardiovascular Diseases: Vascular Biology and Clinical Syndromes, Second Edition offers new discoveries in clinical settings, cellular, molecular, genetic, and epigenetic mechanisms which have led to novel understanding of the key role of endothelium in both cardiovascular and non-cardiovascular diseases. The innovations it presents have implications for both pathophysiological concepts and clinical decisions. Among other topics, cardiovascular and pulmonary medicine, immunity and inflammation, genetics and epigenetics, heart failure, renal disease, familial hypercholesterolemia, diabetes, and hypertension are discussed at length.With 20 new chapters covering everything from endothelium transition to connective tissue disorders, this second edition is sure to be indispensable to anyone wishing to learn the importance of endothelium to every facet of health.- Examines the ways in which endothelium relates to almost every cardiovascular and systemic disease- Provides a critical, in depth, pathophysiological review of endothelium which cannot be found in any other single volume- Offers cutting-edge, critical knowledge for investigators and practitioners alike, information which has evolved rapidly since the previous edition
Table of Contents
1. Signal Transduction Pathways in Endothelial Cells: Implications for Angiogenesis2. Endothelial Barrier: Factors That Regulate Its Permeability3. Hemodynamic Forces in the Endothelium: From Mechanotransduction to Implications on Development of Atherosclerosis4. Endothelium-Dependent Vasodilation: Nitric Oxide and Other Mediators5. Vasoconstrictor Substances Produced by the Endothelium6. Redox Cellular Signaling Pathways in Endothelial Dysfunction and Vascular Disease7. Endothelium and Immune System8. Progenitor Cells - Origins and Endothelium Regeneration9. Blood Coagulation and Endothelium10. Platelets and Endothelium11. Endothelium and Genetics12. Regulation of Endothelial Function: With Focus RNAs, MicroRNAs, and LncRNAs13. Endothelium and Renin-Angiotensin System14. Methods to Investigate Endothelial Function in Humans15. Endothelium to Mesenchymal Transition - Contributions to Vascular Diseases16. Endothelial Products as Plasmatic Biomarker of Vascular Dysfunction17. Endothelial Alterations in Aging18. Vascular Function and Cognitive Decline19. Emotional Stress and Influences on Endothelium20. Cardiac Arrhythmias and Endothelium21. Lipids and Lipoprotein Mediators of Endothelial Function and Dysfunction22. Non-HDL Particles, Triglycerides and Endothelium - NEW CHAPTER23. Risk Factors for Endothelial Dysfunction and Early Onset of Cardiovascular Diseases in the Young24. Endothelial Dysfunction and Myocardial Injury in COVID-1925. Colchicine for the Prevention of Cardiovascular Disease26. Venous Thromboembolism and Endothelium27. Artificial Lipoproteins in Endothelial Dysfunction and Atherosclerosis28. Influences of Diet on Endothelial Dysfunction29. Endothelium and Microbiota as Regulators of Metabolic Process30. Effects of Red Wine and Polyphenols on Endothelial Function and Clinical Events31. Kidney and the Endothelium32. Endothelial Alterations in Pulmonary Hypertension33. Endothelial Alterations in Chronic Coronary Disease34. Molecular Mechanisms of the Arterial Wall in Acute Coronary Syndromes35. Integrating Multiomic Approaches to Uncover Candidate Gene Networks for Endothelial Dysfunction in Response do CVD Risk Factors36. Endothelium - Coordinator of Acute and Chronic Inflammation37. Endothelium in Atherosclerosis: Plaque Formation and Its Complications38. Endothelial Function and Cardiovascular Risk Factors Interactions39. Sleep Disorders and Endothelial Dysfunction40. Smoking and the Endothelium41. Effects of radiation upon Vascular Endothelium42. Endothelial Dysfunction and Coronary Microvascular Dysfunction in Women with Angina and Non-obstructive Coronaries43. Endothelial Alterations in Heart Failure—Mechanisms and Molecular Basis44. Endothelium Function in HF with Preserved EF45. Endothelium in Cardiomyopathies46. Post percutaneous Interventions: Endothelial Repair47. Stents and the Endothelium48. Vascular Disease of the Transplanted Heart: Physiopathology and Therapeutic Options49. Erectile Dysfunction and the Endothelium50. Cardiovascular Actions and Therapeutic Implications of Endothelium-Derived Catecholamines51. Obesity, Endothelium and Metabolic Syndrome52. Endothelium in Diabetes53. Endothelial Mechanisms in Preeclampsia54. Angiogenesis and Tumor Vasculature Function55. Corneal Endothelium Cell Dysfunction56. Connective Tissue and Endothelium57. Physical Exercise and the Endothelium58. The Translational Concept in Endothelium - From Research to Clinical Practice59. Advancements in Understanding the Interplay between Endothelial Dysfunction and Arterial Hypertension
