Semisynthesis of Bioactive Compounds and their Biological Activities

著者名：Majhi, Sasadhar/Manickam, Sivakumar

Elsevier（2023/11/25発売）

• 言語：ENG
• ISBN：9780443152696
• eISBN：9780443152702

Description

Semisynthesis of Bioactive Compounds and their Biological Activities explores the potential benefits of semisynthetic derivatives obtained from nature. Sections cover the natural distribution of parent compounds, semisynthesis and biological properties of semisynthetic derivatives, the applications of semisynthetic derivatives in diverse fields such as drug delivery, food production and medicine, an explanation of the current resistance mechanisms of antibiotics, clinical applications of semisynthetic analogues, the functions of plant alkaloids on human health, potential agricultural biotechnology in semisynthetic derivatives, and semisynthesis of natural products under greener conditions, this book provides a comprehensive resource on the topics presented.Sections include information about alternative sources of energy and superior greener technologies (microwave, sonochemistry), alternative reaction media (water, supercritical CO2, ionic liquids) and alternative eco-friendly catalysts (biocatalysts). This book will be an excellent resource for academicians, researchers and students focusing on synthesis as well as the biological community and industry professionals in drug development.- Focuses on the current resistance mechanisms of antibiotics, chemical derivatization of antibiotics, and clinical applications of semisynthetic derivatives.- Includes discussion of the semisynthesis of natural products using green tools, green solvents, and eco-friendly catalysts.- Illustrates the concept of toxicity, the merits of transition-metal-free reactions, and the semisynthesis of natural products by introducing the oxygen atom(s) under transition-metal-free conditions.

Table of Contents

1. Introduction2. Semisynthesis of Antibiotics3. Semisynthesis of Alkaloids4. Semisynthesis of Flavones5. Semisynthesis of Lignans6. Semisynthesis of Phenolic Compounds7. Semisynthesis of Anthocyanins8. Semisynthesis of Natural Products at Room Temperature (R2)9. Semisynthesis of Natural Products under Greener Conditions10. Semisynthesis of Natural Products through Insertion of Oxygen Atom under Metal-free Conditions11. An adaptation of organic reactions in the bioactive compounds industry (R1)12. Regulatory aspects of the novel derivative as nutraceuticals (R1)13. Computational chemistry of Natural Product Analogues (R2)14. Semi-synthesis for neglected and tropical diseases (R2)