Description
Tailor-Made and Functionalized Biopolymer Systems: For Drug Delivery and Biomedical Applications covers the design and application of these functionalized and tailor-made biopolymers and biopolymer systems intended for drug delivery and biomedical applications. Various concepts, design protocols and biomedical applications of tailor-made biopolymer systems are covered, guiding the reader from theoretical knowledge to practical application. Authored by an array of experts from global institutions, this book offers an interdisciplinary approach to how tailor-made biopolymers lead to novel drug delivery and treatment solutions. This will be a useful reference to a broad audience, including biomedical engineers, materials scientists, pharmacologists and chemists.- Provides a concise overview of tailor-made and functionalized biopolymer systems for biomedical applications- Covers a range of modified biopolymers, biopolymeric composites and biopolymer-based systems in drug delivery, development of artificial organs, diagnostic applications, and more- Describes characterization, synthesis and functionalization of biopolymers and biopolymers systems
Table of Contents
List of contributors xv1 Introduction to tailor-made biopolymers in drug deliveryapplicationsYasir Faraz Abbasi, Parthasarathi Panda, Sanjay Arora, Buddhadev Layekand Hriday Bera1.1 Introduction1.2 Biopolymers from plant and animal kingdom1.2.1 Polysaccharides1.2.2 Polypeptides1.2.3 Polynucleotides1.3 Chemical modifications of biopolymers1.3.1 Modification approaches of polysaccharides1.3.2 Modification approaches of polypeptides1.4 Tailor-made biopolymers as pharmaceutical excipients1.5 ConclusionReferencesSection 1 Modified biopolymers2 Thiolated biopolymers in drug delivery and biomedical applicationsCustodiana A. Colmenarez Lobo, Mirta L. Fascio and Norma B. D'Accorso2.1 Introduction2.2 Thiolated biopolymers in drug delivery applications2.3 Thiolated biopolymers in biomedical applications2.3.1 Medicinal applications2.3.2 Diagnosis2.3.3 Regenerative medicine2.4 Conclusion and future perspectivesAcknowledgmentsReferences3 Smart biopolymers for controlled drug delivery applicationsSanjay Arora, Riddhi Trivedi, Richard N.L. Lamptey, Bivek Chaulagain,Buddhadev Layek and Jagdish Singh3.1 Introduction3.2 Different types of smart biopolymers3.2.1 Thermosensitive smart polymers3.2.2 pH-sensitive smart polymers3.2.3 Light-sensitive smart polymers3.2.4 Phase-sensitive smart polymers3.2.5 Bioresponsive smart polymers3.3 ConclusionReferences4 Alginate-based systems for protein and peptide deliveryParamita Paul, Gouranga Nandi, Mohammed A. Abosheasha andHriday Bera4.1 Introduction4.2 Alginate: sources, physicochemical and biological properties4.2.1 Sources of alginates4.2.2 Physicochemical properties4.2.3 Biological properties4.3 Modifications of alginate for protein and peptide delivery4.3.1 Covalent chemical modifications4.3.2 Polyelectrolyte complexes4.4 Alginate-based systems for protein and peptide delivery4.4.1 Model protein delivery4.4.2 Insulin delivery4.4.3 Angiogenic factor delivery4.4.4 Chemokine delivery4.4.5 Bone morphogenetic protein delivery4.5 ConclusionReferences5 Chitosan-based polyelectrolyte complexes in biomedicalapplicationsBuddhadev Layek, Surajit Das and Shubhajit Paul5.1 Introduction5.2 Polyelectrolyte complexes5.2.1 Mechanism of polyelectrolyte complexes formation5.2.2 Preparation of PECs and factors influencing the formationand stability of PECs5.3 Applications of chitosan-based polyelectrolyte complexes5.3.1 Drug delivery5.3.2 Gene delivery5.3.3 Tissue engineering5.4 ConclusionReferences6 Tailor-made cyclodextrin-based nanomaterials as drug carriersKazi Ali, Pradyot Roy, Arindam Maity and Pranabesh Chakraborty6.1 Introduction6.1.1 History6.1.2 Source of cyclodextrins6.1.3 Types and structure of cyclodextrins6.1.4 Properties of cyclodextrins6.1.5 Inclusion complex formation6.2 Modification of cyclodextrins6.2.1 Principle and chemistry of cyclodextrin modification6.2.2 Characterization of modified cyclodextrins6.3 Cyclodextrin-based nanomaterials6.3.1 Preparation of nanomaterials from cyclodextrins andapplications6.3.2 Different cyclodextrin-based nanomaterials6.4 Pharmaceutical and biomedical applications of tailor-madeCD-based nanomaterials6.5 Conclusion and future prospectsReferencesFurther readingSection 2 Biopolymeric conjugates/composites7 Biopolymer_metal oxide composites in biomedicalapplicationsYasir Faraz Abbasi and Hriday Bera7.1 Introduction7.2 Applications of biopolymer_metal oxide composites7.2.1 Drug delivery7.2.2 Anticancer, antioxidant, and antimicrobial activities7.2.3 Wound healing and tissue engineering7.2.4 Biosensors, bioimaging, and diagnostics7.3 ConclusionReferences8 Biopolymer_drug conjugates as biomaterialsHaifei Guo, Yasir Faraz Abbasi, Hriday Bera and Mingshi Yang8.1 Introduction8.2 Biopolymer_drug conjugates8.2.1 Polysaccharide-drug conjugates8.2.2 Polypeptide_drug conjugates8.
