Description
Psychiatrists and other mental health professionals are increasingly confronted with questions about the genetics of psychiatric illness, and the clinical applications of new genetic findings. Psychiatric Genetics: A Primer for Clinical and Basic Scientists addresses these questions through a straightforward introduction to the essentials of psychiatric genetics, complementing more comprehensive textbooks that may seem overwhelming for those new to the field. Written and edited by leaders in the field and the International Society of Psychiatric Genetics (ISPG), the book covers basic epidemiology, recruitment for human studies, phenotyping strategies, formal genetic and molecular genetic studies, statistical genetics, bioinformatics and genomics, pharmacogenetics, the most relevant animal models, and biobanking. Each chapter begins with a list of "take home" points that summarizes content, followed by a brief overview of current knowledge and suggestions for further reading. This Primer is ideal for medical students, psychiatric residents, psychiatrists, and basic neuroscience researchers who are interested in learning about the key concepts and recent advances in the exciting field of psychiatric genetics.
Table of Contents
Chapter 1: Contribution of Epidemiology to Our Understanding of Psychiatric GeneticsAlison K. Merikangas and Kathleen R. MerikangasChapter 2: Recruitment of Human Subjects: An overview of techniques and methods used in psychiatric and other clinical studiesLayla KassemChapter 3: Basic molecular genetics concepts and tools: from SNPs to chipsSevilla D Detera-Wadleigh, Nirmala Akula, and Liping HouChapter 4: Statistical genetics: Genome-wide studiesTill F.M. Andlauer, Bertram Müller-Myhsok, and Stephan RipkeChapter 5: Human Linkage and Association AnalysisJohn P. RiceChapter 6: The role of copy number variation in psychiatric disordersElliott Rees and George KirovChapter 7: Pharmacogenomics & Precision PsychiatryJulia C. Stingl and Gonzalo LajeChapter 8. EndophenotypesDavid C. Glahn, Laura Almasy, and John BlangeroChapter 9: Imaging GeneticsLuanna Dixson, Heike Tost, and Andreas Meyer-LindenbergChapter 10: Bioinformatics in psychiatric geneticsNikola S. Mueller, Ivan Kondofersky, Gökcen Eraslan, Karolina Worf, and Fabian J. TheisChapter 11: Epigenomic Exploration of the Human BrainTobias B. Halene, Gregor Hasler, Amanda Mitchell, and Schahram AkbarianChapter 12: Epigenetics in PsychiatrySubha Subramanian and James B. PotashChapter 13: Next-generation sequencing in genetic studies of psychiatric disordersShweta Ramdas and Jun Z. LiChapter 14: Animal ModelsTadafumi KatoChapter 15: Biobanking of Human Induced Pluripotent Stem Cells for Psychiatric ResearchJennifer C. Moore, Michael Sheldon, and Jay A. Tischfield
