Description
Models of Seizures and Epilepsy, Second Edition, is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models to address key questions in the field. The book also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research as well as R&D drug development. Contents include the current spectrum of models available to model different epilepsy syndromes, epilepsy in transgenic animals, comorbidities in models of epilepsy, and novel technologies to study seizures and epilepsies in animals.- Provides a comprehensive reference detailing animal models of epilepsy and seizure- Offers insights on the use of novel technologies that can be applied in experimental epilepsy research- Edited by leading experts in the field that provide not only technical reviews of these models but also conceptual critiques- Comments on the strengths and limitations of various models, including their relationship to clinical phenomenology and their value in developing better understanding and treatments
Table of Contents
Introduction1. What can we model?2. Comparative biology and species effects on expression of epilepsy3. Strain effects on expression of seizures and epilepsy4. Good welfare practice in modeling seizures and epilepsy5. Ethics in the Use of Animal Models of Seizures and Epilepsy6. Regulatory aspects of drug development7. Use of animal models for epilepsy research and therapy developmentTechnical and methodological issues 8. Monitoring for Seizures in Rodents9. Behavioral characterization and scoring of seizures in rodents10. Seizure mimics11. Characterization of pathology12. Monitoring cardiorespiratory and other physiological parameters during seizures in small animals13. Behavioral and cognitive testing procedures in animal models of epilepsy14. In vivo Imaging in rodentsIn vitro and in silico models 15. Hippocampal in silico models of seizures and epilepsy16. Neocortical/thalamic in silico models of seizures and epilepsy17. iPS cells, stem cells18. Hippocampus in vitro19. Thalamus and cortex in vitro20. Brain slices from human resected tissues21. Organotypic Hippocampal Slice cultures as a Model of Post-traumatic Epileptogenesis22. The in vitro isolated guinea pig brain in the study of ictogenesisNon-mammalian in vivo models 23. Nematode C. elegans: Genetic Dissection of Pathways Regulating Seizure and Epileptic-like Behaviors 24. Drosophila25. Xenopus laevis26. Zebrafish models of epilepsy and epileptic seizuresNaturally occurring seizures and epilepsies in animals27. Veterinarian's perspective28. Naturally occurring epilepsy and status epilepticus in dogs29. Naturally Occurring Temporal Lobe Epilepsy in Cats30. Naturally occurring epilepsy and status epilepticus in Sea lions31. Baboon Model of Genetic Generalized Epilepsy32. Genetic Models of Reflex Epilepsy and SUDEP in Rats and Mice33. Genetic models of absence epilepsy in rats and miceIn vivo mammalian models of induced seizures and status epilepticus 34. Electrical stimulation35. Systemic Chemoconvulsants Producing Acute Seizures in Adult Rodents36. Focally applied chemoconvulsants37. Models of Chemically-Induced Acute seizures and Epilepsy: Toxic compounds and drugs of addiction38. Pharmacologically induced animal models of absence seizures39. Models of seizures and status epilepticus early in lifeIn vivo mammalian models of acquired epilepsies40. Tetanus toxin41. Post-SE models: Systemic kainic acid42. Post-SE models: Focal kainic acid43. The Pilocarpine Model of Acquired Epilepsy44. Post-Status Epilepticus models: Electrical stimulation45. Post-SE models: Hyperthermia46. Epilepsy after TBI47. Post-infectious epilepsy48. Post-perinatal hypoxia49. Perinatal Hypoxic-Ischemic Encephalopathy: A Model of Stroke-Induced Pediatric Epilepsy50. Post-stroke epilepsy51. Animal Models of Drug-Refractory EpilepsyIn vivo mammalian models of genetic epilepsies with identified gene52. Spontaneous and Gene-Directed Epilepsy Mutations in the Mouse53. Dravet and GEFS+ syndromes54. Tuberous sclerosis and other toropathiesModeling conditions that predispose to seizures or epilepsy55. Kindling (including fast and slow kindlers)56. Human mutations associated with brain malformations resulting in hyperexcitability in rodents57. Dysplasias - Cortical freeze lesion58. Dysplasia – MAM, model of developmental epilepsy59. Dysplasias - In utero irradiation60. Undercut cortex61. Brain tumor–related epilepsy62. Withdrawal seizures63. Perimenstrual seizures and neurosteroid withdrawal64. Metabolic disturbances: Hypo- and hyperglycemic seizures in vivo and in vitro65. Stress66. Blood Brain Barrier disruption67. Experimental models of inflammation in epilepsy researchOther specific epilepsy-related syndromes 68. Infantile spasms69. Models of epileptic encephalopathies70. Sudep Animal ModelsAnimal models of other brain diseases with altered seizure susceptibility71. Epilepsy in Models of Alzheimer's disease72. Animal Models of Acquired Epilepsy and Tauopathies73.
