Description
Handbook of the Biology of Aging, Eighth Edition, provides readers with an update on the rapid progress in the research of aging. It is a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology, and focuses on the trend of 'big data' approaches in the biological sciences, presenting new strategies to analyze, interpret, and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and the metabolomics methodologies applied to aging related problems.The book includes discussions on longevity pathways and interventions that modulate aging, innovative new tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, new strategies to pharmacologically modulate the mTOR pathway to delay aging, the importance of sirtuins and the hypoxic response in aging, and how various pathways interact within the context of aging as a complex genetic trait, amongst others.- Covers the key areas in biological gerontology research in one volume, with an 80% update from the previous edition- Edited by Matt Kaeberlein and George Martin, highly respected voices and researchers within the biology of aging discipline- Assists basic researchers in keeping abreast of research and clinical findings outside their subdiscipline- Presents information that will help medical, behavioral, and social gerontologists in understanding what basic scientists and clinicians are discovering- New chapters on genetics, evolutionary biology, bone aging, and epigenetic control- Provides a close examination of the diverse research being conducted today in the study of the biology of aging, detailing recent breakthroughs and potential new directions
Table of Contents
ForewordPrefaceSection I: Basic Mechanisms of Aging: Models and SystemsChapter 1 – Longevity as a Complex Genetic TraitGeorge L. Sutphin and Ron KorstanjeChapter 2 – The mTOR Pathway and AgingKatherine H. Schreiber, Monique N. O'Leary, and Brian K. KennedyChapter 3 – Sirtuins, Healthspan, and Longevity in MammalsWilliam Giblin and David B. LombardChapter 4 – The Hypoxic Response and AgingScott F. Leiser, Hillary A. Miller, and Matt KaeberleinChapter 5 – The Role of Neurosensory Systems in the Modulation of AgingMichael J. Waterson and Scott D. PletcherChapter 6 – The Naked Mole-Rat: A Resilient Rodent Model of Aging, Longevity, and HealthspanKaitlyn N. Lewis and Rochelle BuffensteinChapter 7 – Contributions of Telomere Biology to Human Age-Related DiseaseTing-Lin B. Yang, Shufei Song, and F. Brad JohnsonChapter 8 – Systems Approaches to Understanding AgingLei Hou, Dan Wang, Hao Cheng, Bo Xian, and Jing-Dong J. HanChapter 9 – Integrative Genomics of AgingJoão Pedro de Magalhães and Robi TacutuChapter 10 – NIA Interventions Testing Program: A Collaborative Approach for Investigating Interventions to Promote Healthy AgingNancy L. Nadon, Richard A. Miller, Randy Strong, and David E. HarrisonChapter 11 – Comparative Biology of Aging: Insights from Long-Lived Rodent SpeciesMichael Van Meter, Vera Gorbunova, and Andrei SeluanovSection II: The Pathobiology of Human AgingChapter 12 – Genetics of Human AgingMiook Cho and Yousin SuhChapter 13 – The Aging Arterial WallMingyi Wang, Robert E. Monticone, and Edward G. LakattaChapter 14 – Age-Related Alterations in Neural PlasticityShannon J. Moore and Geoffrey G. MurphyChapter 15 – The Aging Immune System: Dysregulation, Compensatory Mechanisms, and Prospects for InterventionLudmila Müller and Graham PawelecChapter 16 – Vascular Disease in Hutchinson Gilford Progeria Syndrome and Aging: Common Phenotypes and Potential MechanismsIngrid A. Harten, Michelle Olive, and Thomas N. WightChapter 17 – Cardiac AgingDao-Fu Dai, Ying-Ann Chiao, Robert J. Wessells, Rolf Bodmer, Hazel H. Szeto, and Peter S. RabinovitchChapter 18 – Current Status of Research on Trends in Morbidity, Healthy Life Expectancy, and the Compression of MorbidityEileen M. Cr4immins and Morgan E. LevineChapter 19 – On the Compression of Morbidity: From 1980 to 2015 and BeyondJames F. Fries
