Description
Viral Pathogenesis: From Basics to Systems Biology, Third Edition, has been thoroughly updated to cover topical advances in the evolving field of viral pathogenesis, while also providing the requisite classic foundational information for which it is recognized.The book provides key coverage of the newfound ability to profile molecular events on a system-wide scale, which has led to a deeper understanding of virus-host interactions, host signaling and molecular-interaction networks, and the role of host genetics in determining disease outcome.In addition, the content has been augmented with short chapters on seminal breakthroughs and profiles of their progenitors, as well as short commentaries on important or controversial issues in the field. Thus, the reader will be given a view of virology research with perspectives on issues such as biomedical ethics, public health policy, and human health. In summary, the third edition will give the student a sense of the exciting new perspectives on viral pathogenesis that have been provided by recent developments in genomics, computation, modeling, and systems biology.- Covers all aspects of viral infection, including viral entry, replication, and release, as well as innate and adaptive immunity and viral pathogenesis- Provides a fresh perspective on the approaches used to understand how viruses cause disease- Features molecular profiling techniques, whole genome sequencing, and innovative computational methods- Highlights the use of contemporary approaches and the insights they provide to the field
Table of Contents
Viral Pathogenesis: From Basics to Systems Biology1. The Human Toll of Viral Diseases: Past plagues and pending pandemicsNeal Nathanson2. Historical Roots: The family tree of viral pathogenesisWilliam C. Summers3. Basic Concepts: A step-by-step guide to viral infectionRobert Doms4. Innate Immunity: Recognizing and responding to foreign invaders—no training neededChristine A. Biron5. Adaptive Immunity: Neutralizing, eliminating, and remembering for the next timeE. John Wherry, David Masopust6. Aberrant Immunity: The consequences of overreacting or underperformingE. John Wherry, David Masopust7. Patterns of infection: Unwanted guests—quick visits and extended staysNeal Nathanson and Francisco González-Scarano8. Viral Oncogenesis: Infections That Can Lead to CancerNicholas A. Wallace and Denise A. Galloway9. HIV and AIDS: Science wrestles with 10,000 nucleotides—points but no pinGuido Silvestri and Emily Cartwright10. Animal Models: No model is perfect, but many are usefulVictoria K. Baxter and Diane E. Griffin11. Systems Virology: Why Everybody Wants To Measure EverythingMarcus J. Korth and G. Lynn Law12. The Virus-Host Interactome: Knowing the players to understand the gameMonika Schneider, Jeffery R. Johnson, Nevan J. Krogan, and Sumit K. Chanda13. Host Genetics: It's not just the Virus, StupidMartin T. Ferris, Mark T. Heise, and Ralph S. Baric14. Host metabolomics: Yet more ways your health is influenced by fatPriscilla Yang15. Mathematical Modeling: Solving equations to measure viral diseases – math rulesAlan S Perelson16. Emerging viral diseases: Why we need to worry about bats, camels, and airplanesJames W. Le Duc and Neal Nathanson17. Viral evolution: It's all about mutationsAdi Stern and Raul Andino18. Viral Epidemiology: Tracking viruses with smartphones and social mediaKaitlin Rainwater-Lovett, Isabel Rodriguez-Barraquer and William J. Moss19. Viral Vaccines: Fighting viruses with virusesJuliet Morrison and Stanley Plotkin20. Antiviral TherapyDouglas D. Richman and Neal Nathanson21. Breakthrough: Nobel prize discoveries in viral pathogenesisNeal Nathanson22. What lies ahead? Scientists look into their crystal balls
