基本説明
Outstanding combination of the latest clinical and scientific data supplemented by color reproductions of the clinical and pathological changes of the skin.
Full Description
- Based on multidisciplinary knowledge and written by leading clinicians and scientists. - Includes chapters on classification and clinical aspects, pathologic features, and treatment and management of lupus erythematosus. - Although the lupus erythematosus is primarily a skin disease, because it can affect other areas such as joints, kidneys, lungs, heart, liver, brain, and blood vessels this book is also useful to specialists in internal medicine.
Contents
Introduction: Historical background of cutaneous lupus erythematosus.- What is autoimmunity? Basic mechanisms and concepts.- The epidemiology of cutaneous lupus erythematosus.- Pathogenesis of cutaneous lupus erythematosus. Clinical Aspects of Cutaneous Lupus Erythematosus: Classification and clinical manifestations of cutaneous lupus erythematosus.- Nonspecific cutaneous manifestations of systemic lupus erythematosus.- Cutaneous lupus erythematosus during the neonatal and childhood periods.- Drug-induced lupus erythematosus.- Association of cutaneous lupus erythematosus with other dermatologic diseases.- Cutaneous manifestations of the antiphospholipid syndrome.- Relationship between cutaneous and systemic lupus erythematosus.- Photosensitivity of cutaneous lupus erythematosus.- Clinical differential diagnoses of cutaneous lupus erythematosus.- Prognosis of cutaneous lupus erythematosus. Pathology of Cutaneous Lupus Erythematosus: Histologic findings in cutaneous lupus erythematosus.- Immunopathology of cutaneous lupus erythematosus.- Laboratory features of cutaneous lupus erythematosus.- Antinuclear autoantibodies in cutaneous lupus erythematosus: biochemical and cell biological characterization of Ro/SSA.- Photoimmunology.- Experimental models of lupus erythematosus.- Molecular genetics of cutaneous lupus erythematosus.- Apoptosis in lupus erythematosus.- The role of dendritic cells in cutaneous lupus erythematosus.- The role of T cells and adhesion molecules in cutaneous lupus erythematosus. Therapy of Cutaneous Lupus Erythematosus: Topical treatment of cutaneous lupus erythematosus.- Antimalarials.- Retinoids and Dapsone.- Immunosuppressive drugs in cutaneous lupus erythematosus.- Thalidomide in cutanoeus lupus erythematosus.- Experimental therapies in cutaneous lupus erythematosus.- Management of cutaneous lupus erythematosus. Concluding Remarks.
