Neuroinflammation in Stroke (Ernst Schering Research Foundation Workshop Vol.47) (2004. 260 p. w. 35 ill.)


Neuroinflammation in Stroke (Ernst Schering Research Foundation Workshop Vol.47) (2004. 260 p. w. 35 ill.)

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  • 製本 Hardcover:ハードカバー版/ページ数 260 p.
  • 商品コード 9783540403487

Full Description

Stroke is a major cause of death and disability in industrialized countries. To date, the medical need of efficient therapy for this de- vastating cerebrovascular disorder remains unmet. During the last decades, the development of pharmacological stroke therapies was aimed at improving patient outcome by restoration of cerebral blood flow or protection from acute neuronal cell death. Almost all of The participants of the workshop VI Preface these appraaches targeted the very early events after vascular occIu- sion. However, primarily for logistical reasons, only a small portion of strakes can be treated within 6-10 h after the insult. In recent years it has been recognized that strake pathophysiology is a dynamic pracess, and that delayed pracesses, which occur dur- ing the days and weeks following arterial occIusion, may lead to further deterioration or to impairment of recovery and rehabilitation in subacute and chranic stages. Evidence is accumulating that neu- rainflammation is a major player in these delayed pathophysiologi- cal pracesses.While some components of neurainflammation such as removal of cell debris and release of traphic factors may support recovery pracesses, others such as the generation of free radicals and other cytotoxic mediators are deleterious for brain tissue after isch- emia. Thus, neurainflammation after strake can be considered a dou- ble-edged sword, having potentially both detrimental and beneficial effects. As in other inflammatory reactions in the body, the cellular and humoral interactions are highly complex in the setting of neu- rainflammation.

Table of Contents

  1 Matrix Metalloproteinases In
Neuroinflammation and Cerebral Ischemia
G.A. Rosenberg, S. Mun-Bryce 1 (16)
2 Involvement of Tight Junctions During
Transendothelial Migration of Mononuclear
Cells in Experimental Autoimmune
H. Wolburg, K. Wolburg-Buchholz, B. 17 (22)
3 Cytokines in Stroke
S. Allan, C. Stock 39 (28)
4 Complement Activation: Beneficial and
Detrimental Effects in the CNS
J. Van Beek 67 (20)
5 Inflammation in Stroke: The Good, the Bad,
and the Unknown
U. Dirnagl 87 (14)
6 Tetracycline Derivatives as
Anti-inflammatory Agents and Potential Agents
in Stroke Treatment
J. Koistinaho, J. Yrjanheikki, T. 101(16)
Kauppinen, M. Koistinaho
7 Induction of Mucosal Tolerance to
E-Selectin Targets Immunomodulation to
Activating Vessel Segments and Prevents
Ischemic and Hemorrhagic Stroke
H. Takeda, M. Spatz, C. Ruetzler, R. 117(16)
McCarron, K. Becker, J. Hallenbeck
8 Protective Autoimmunity and Prospects for
Therapeutic Vaccination Against
Self-Perpetuating Neurodegeneration
M. Schwartz 133(22)
9 Lessons from Stroke Trials Using
Anti-inflammatory Approaches That Have Failed
G.J. del Zoppo 155(30)
10 Inflammation-Mediated Damage as a Potential
Therapeutic Target in Acute Ischemic Stroke
A. Chamorro, A.M. Planas 185(20)
11 Design Issues in Selected Recent or Ongoing
Stroke Trials
M. Schwaninger, P. Ringleb, W. Hacke 205(12)
Subject Index 217(4)
Previous Volumes Published in This Series 221