Full Description
This volume describes 11 new yet validated and tested analytical methods for determining susceptibility markers in body fluids. The result is a crucial and authoritative contribution towards an individualized risk assessment with respect to occupational toxicants. A detailed description of the analytical procedures is accompanied by chapters on the biochemical basis of markers of susceptibility as well as guidelines on how to evaluate the analytical results. These recommendations have been established by the Senate Commission on the Investigation of Health Hazards of Chemical Compounds, a division of the Deutsche Forschungsgemeinschaft (DFG). The Commission is internationally acknowledged for its neutrality and is working strictly according to transparent, scientific criteria. The editor of this work is head of the Commission's working group "Analytical Chemistry".
Contents
Introduction: Susceptibility and Biological Monitoring; Susceptibility and Analytical Methods; The Polymerase Chain Reaction and Its Application in Occupation and Environmental Medicine; Cytochrome P450 1A1 (Genotyping); Cytochrome P450 1B1 (Genotyping); Cytochrome P450 2E1 (Genotyping); N-Acetyltransferase 2 (Genotyping); N-Acetyltransferase 2 (Phenotyping: Caffeine Test); Glutathione S-transferase T1 and M1 (Genotyping); Glutathione S-transferase T1 (Phenotyping); Glutathione S-transferase P1 (Genotyping); Sulphotransferase 1A1 and 1A2 (Genotyping); Glucose-6-phosphate dehydrogenase (Phenotyping); Short Guidelines for Real Time PCR Genotyping: CYP1A1 IVA,; CYP1A1 Msp I, CYP2E1 Rsa I, GSTM1 and GSTT1, GSTP1)
