Full Description
In this book, experts in the field express their well-reasoned opinions on a range of complex, clinically relevant issues across the full spectrum of cell and gene therapies with the aim of providing trainee and practicing hematologists, including hematopoietic transplant physicians, with information that is relevant to clinical practice and ongoing research. Each chapter focuses on a particular topic, and the concise text is supported by numerous working tables, algorithms, and figures. Whenever appropriate, guidance is provided regarding the availability of potentially high-impact clinical trials. The rapid evolution of cell and gene therapies is giving rise to numerous controversies that need to be carefully addressed. In meeting this challenge, this book will appeal to all residents, fellows, and faculty members responsible for the care of hematopoietic cell transplant patients. It will also offer a robust, engaging tool to aid vital activities in the daily work of every hematology and oncology trainee.
Contents
Historical perspective and current focus.- Part I: Genetically modified T cells (Chimeric antigen receptors and T cell receptors): Chimeric antigen receptor-T cells: Antigen selection, CAR development and future prospects.- Chimeric antigen receptor-T cells for leukemias in children: Methods, data and challenges.- Chimeric antigen receptor-T cells for leukemias in adults- Methods, data and challenges.- Chimeric antigen receptor-T cells for lymphomas: Methods, data and challenges.- T-cell receptors-gene modified T-cells for cancer.- Methods, data and challenges..- Part II: Beyond chimeric antigen receptor and T-cell receptors - Data, Consensus & Challenges: Cytotoxic T cells for infections: From donor-specific to "off the shelf".- Donor lymphocyte infusion in different transplant settings: When and how?- T-regulatory cells: Broadening applicability.- Tumor infiltrating lymphocytes: Current concepts and practices.- Part III: Beyond T-cells: Natural killercells: What have we learned?- Dendritic cells in hematopoietic cell transplantation.- Mesenchymal stem cells: From bench to bedside and back.- Cell Therapies: Regulatory concerns and data collection.- Part IV: Gene Therapy: Gene therapy for hematologic malignancies and in transplant setting .- Gene therapy for nonmalignant disorders.- Future prospects of cell and gene therapies.
