Full Description
This textbook provides a profound overview on comparative oncology covering both the background of the discipline and its underlying principles. It also shows how comparative oncology can be utilized to advance human research. Illustrated by numerous images the book vastly covers current knowledge about comparative aspects of different tumor types such as mammary, prostate or bladder carcinoma. An emphasis is placed on companion animals, but information on other animal models is also included.
In recent years, comparative oncology has become a major topic in human and veterinary medicine. This book now provides a unique and comprehensive look at the field, offering in-depth knowledge to graduate and advanced undergraduate students, as well as researchers working in both fields. Clinicians will particularly appreciate the insights on diagnostics and treatment strategies.
Contents
Part I: Background in comparative oncology.- Introduction.- Benefit of comparative oncology for human populations.- Cancer pathogenesis in non-human species.- Comparative immunology of dogs.- Part II: Comparative cancer diagnosis and treatment.- Comparative pathology.- Comparative radiobiology and radiation therapy: adverse events difference in species.- Comparative aspects of chemotherapy and targeted therapy: how different species process drugs.- Comparative aspects of surgical oncology: Musculoskeletal.- Part III: Specific tumors.- Osteosarcoma.- Lymphoma.- Urothelial carcinoma.- Melanoma.- Head and neck cancer.- Glioma.- STS.- Part IV: Utilizing comparative oncology approaches.- Randomized controlled clinical trials in dogs: drug development, treatment protocols, pharmacokinetics.- Clinical trials with device or technology development including imaging technology also treatment adverse events and treatment resistance.- Integrated clinical trials in dogs and humans including histologically agnostic approaches and personalized medicine.
