Full Description
Translational Neuroscience offers a far-reaching and insightful series of perspectives on the effort to bring potentially revolutionary new classes of therapies to the clinic, thereby transforming the treatment of human nervous system disorders. Great advances in the fields of basic neuroscience, molecular biology, genomics, gene therapy, cell therapy, stem cell biology, information technology, neuro devices, rehabilitation and others over the last 20 years have generated unprecedented opportunities to treat heretofore untreatable disorders of the nervous system. This book provides a wide-ranging yet detailed sample of many of these efforts, together with the methods for pursuing clinical translation and assessing clinical outcomes. Among the topics covered are Alzheimer's disease, Parkinson's disease, stroke, multiple sclerosis, epilepsy, motor neuron disease, pain, inborn errors of metabolism, brain tumors, spinal cord injury, neuroprosthetics, rehabilitation and clinical trial design/consideration.
Translational Neuroscience is aimed at basic neuroscientists, translational neuroscientists and clinicians who seek to gain a perspective on the nature and promise of translational therapies in the current era. Both students and established professionals will benefit from the content.
Contents
Introduction.- Gene Therapy of CNS Disorders using Recombinant AAV vectors.- NGF and BDNF Gene Therapy for Alzheimer's Disease.- GDNF and AADC Gene Therapy for Parkinson's Disease.- GAD Gene Therapy for Parkinson's Disease.- Anti-sense Oligonucleotides for Amyotrophic Lateral Sclerosis.- Gene therapy for Inborn Errors of Metabolism: Batten Disease.- Gene Therapy for Spinal Cord Injury.- Gene Therapy for Epilepsy.- Translating Gene Therapy for Pain from Animal Studies to the Clinic.- Stem Cells for Parkinson's Disease.- Could Stem Cells be used to treat or model Alzheimer's Disease?.- Stem cells for Amyotrophic Lateral Sclerosis.- Stem cells for Multiple Sclerosis.- Cell Therapy for Pediatric Disorders of Glia.- Neural Stem Cells for Spinal Cord Injury.- Marrow-derived Mesenchymal Stromal Cells in the Treatment of Stroke.- Glioma Stem Cells.- Discovery of Potent Gamma Secretase Modulators for the Treatment of Alzheimer's Disease.- Blocking the Nogo-A signalling pathway to promote regeneration and plasticity after spinal cord injury and stroke.- Intrinsic neuronal mechanisms in axon regeneration after spinal cord injury.- Voltage-gated ion channels as molecular targets for pain.- Rehabilitation-dependent neural plasticity after Spinal Cord Injury.- Neural Prostheses for Neurotrauma.- Why is Functional Electrical Stimulation Therapy Capable of Restoring Motor Function Following Severe Injury to the Central Nervous System? .- Deep Brain Stimulation for Neuropsychiatric Disorders.- Novel Interventions for Stroke: Nervous System Cooling.- Rehabilitation Strategies For Restorative Approaches After Stroke and Neurotrauma.- Bridging the Chasm between Scientific Discovery and a Pivotal Clinical Trial for a CNS Disorder: A Checklist.- Conclusion.
