基本説明
血液学の世界的エキスパートを集めて、最新最良の診断・治療を患者に提供できるよう編纂された名テキスト、ホフマンの改訂第６版。
Provides the complete contents online at www.expertconsult.com, with a downloadable image collection, regular updates, case studies, patient information sheets, and more. Prev. ed.: 2008.
Full Description
This leading text reflects both the new direction and explosive growth of the field of hematology. Edited and written by practitioners who are the leaders in the field, the book covers basic scientific foundations of hematology while focusing on its clinical aspects. This edition has been thoroughly updated and includes ten new chapters on cellular biology, haploidentical transplantation, hematologic manifestations of parasitic diseases, and more. The table of contents itself has been thoroughly revised to reflect the rapidly changing nature of the molecular and cellular areas of the specialty. Over 1,000 vivid images, now all presented in full color for the first time, include a collection of detailed photomicrographs in every chapter, selected by a hematopathology image consultant. What's more, this Expert Consult Premium Edition includes access to the complete contents of the book online, fully searchable and updated quarterly by Dr. Hoffman himself.Make confident, effective clinical decisions by consulting the world's most trusted hematology reference. Access the complete contents online at www.expertconsult.com, with a downloadable image collection, regular updates, case studies, patient information sheets, and more.Apply all the latest knowledge on regulation of gene expression, transcription splicing, and RNA metabolism; pediatric transfusion therapy; principles of cell-based gene therapy; allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia and myelodysplastic syndrome in adults; hematology in aging; and much more, thanks to 27 brand-new chapters plus sweeping updates throughout.Find the information you need quickly and easily thanks to a completely reworked organization that better reflects today's clinical practice.Visualize clinical problems more clearly with new and updated images that reflect the pivotal role of hematopathology in modern practice.Benefit from the experience and fresh perspective of new editor Dr. Jeffrey Weitz, Professor of Medicine at McMaster University School of Medicine and Executive Director of the Thrombosis and Atherosclerosis Research Institute in Ontario.Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. If the next edition is published less than one year after your purchase, you will be entitled to online access for one year from your date of purchase. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should access to the web site be discontinued.
Contents
PART I1 Anatomy and Pathophysiology of the Gene2 Genomic Approaches to Hematology3 Regulation of Gene Expression, Transcription, Splicing, and RNA Metabolism4 Protein Synthesis, Processing, and Trafficking5 Protein Architecture: Relationship of Form and Function6 Signaling Transduction and Regulation of Cell Metabolism7 Pharmacogenomics and Hematologic DiseasesPART II: Cellular Basis of Hematology8 Hematopoietic Stem Cell Biology9 Hematopoietic Microenvironment10 Cell Adhesion11 Hematopoietic Cell Trafficking and Chemokines12 Dynamic Interactions between Hematopoietic Stem and Progenitor Cells and the Bone Marrow: Current Biology of Stem Cell Homing and Mobilization13 Vascular Growth in Health and Disease14 Principles of Cytokine Signaling15 Control of Cell Division16 Cell DeathPART III: Immunologic Basis of Hematology17 Overview and Compartmentalization of the Immune System18 B-Cell Development19 T-Cell Immunity20 Natural Killer Cell Immunity21 Dendritic Cell Biology22 Complement and Immunoglobulin Biology23 Tolerance and AutoimmunityPART IV: Disorders of Hematopoietic Cell Development24 Biology of Erythropoiesis, Erythroid Differentiation, and Maturation25 Granulocytopiesis and Monocytopoiesis26 Thrombocytopoiesis27 Inherited Forms of Bone Marrow Failure28 Aplastic Anemia29 Paroxysmal Nocturnal Hemoglobinuria30 Acquired Disorders of Red Cell, White Cell, and Platelet ProductionPART V: Red Blood Cells31 Pathobiology of the Human Erythrocyte and Its Hemoglobins32 Approach to Anemia in the Adult and Child33 Pathophysiology of Iron Homeostasis34 Disorders of Iron Homeostasis: Iron Deficiency and Overload35 Anemia of Chronic Diseases36 Heme Biosynthesis and Its Disorders: Porphyrias and Sideroblastic Anemias37 Megaloblastic Anemias38 Thalassemia Syndromes39 Pathobiology of Sickle Cell Disease40 Sickle Cell Disease - Clinical Features and Management41 Hemoglobin Variants Associated with Hemolytic Anemia, Altered Oxygen Affinity, and Methemoglobinemias42 Red Blood Cell Enzymopathies43 Red Blood Cell Membrane Disorders44 Autoimmune Hemolytic Anemia45 Extrinsic Nonimmune Hemolytic AnemiasPART VI: Non-Malignant Leukocytes46 Neutrophilic Leukocytosis, Neutropenia, Monocytosis and Monocytopenia47 Lymphocytosis, Lymphocytopenia, Hypergammaglobulinemia and Hypogammaglobulinemia48 Disorders of Phagocyte Function49 Congenital Disorders of Lymphocyte Function50 Histiocytic Disorders51 Lysosomal Storage Diseases: Perspectives and Principles52 Infectious Mononucleosis and Other Epstein-Barr Virus-Associated DiseasesPART VII: Hematologic Malignancies53 Progress in the Classification of Myeloid Neoplasms: Clinical Implications54 Conventional and Molecular Cytogenetic Basis of Hematologic Malignancies55 Pharmacology and Molecular Mechanisms of Antineoplastic Agents for Hematologic Malignancies56 Radiation Therapy in the Treatment of Hematologic Malignancies57 Pathobiology of Acute Myeloid Leukemia58 Clinical Manifestations and Treatment of Acute Myeloid Leukemia59 Myelodysplastic Syndromes: Biology and Treatment60 Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndrome in Adults61 Acute Myeloid Leukemia in Children62 Myelodysplastic and Myeloproliferative Neoplasms in Children63 Pathobiology of Acute Lymphoblastic Leukemia64 Clinical Manifestations and Treatment of Acute Lymphoblastic Leukemia in Children65 Acute Lymphoblastic Leukemia in Adults66 Chronic Myeloid Leukemia67 The Polycythemias68 Essential Thrombocythemia69 Primary Myelofibrosis70 Eosinophilia, Eosinophil-Associated Diseases, Chronic Eosinophil Leukemia, and the Hypereosinophilic Syndromes71 Mast Cells and Systemic Mastocytosis72 The Pathologic Basis for the Classification of Non-Hodgkin and Hodgkin Lymphomas73 Origins of Hodgkin Lymphoma74 Hodgkin Lymphoma: Clinical Manifestations, Staging, and Therapy75 Origin of Non-Hodgkin Lymphoma76 Chronic Lymphocytic Leukemia77 Hairy Cell Leukemia78 Clinical Manifestations and Treatment of Marginal Zone Lymphomas (Extranodal/Malt, Splenic, and Nodal)79 Clinical Manifestations, Staging, and Treatment of Follicular Lymphoma80 Mantle Cell Lymphoma81 Diagnosis and Treatment of Diffuse Large B-Cell Lymphoma and Burkitt Lymphoma82 Virus-Associated Lymphoma83 Malignant Lymphomas in Childhood84 T-Cell Lymphomas85 Plasma Cell Neoplasms86 Waldenstrom Macroglobulinemia and Lymphoplasmacytic Lymphoma87 Immunoglobuin Light-Chain Amyloidosis (Primary Amyloidosis)PART VIII: Comprehensive Care of Patients with Hematologic Malignancies88 Clinical Approach to Infections in the Compromised Host89 Indwelling Access Devices90 Nutritional Issues in Patients with Hematologic Malignancies91 Psychosocial Aspects of Hematologic Disorders92 Pain Management and Antiemetic Therapy in Hematologic Disorders93 Palliative Care94 Late Complications of Hematologic Diseases and Their TherapiesPART IX: Cell-Based Therapies95 Overview and Historical Perspective of Cell-Based Therapies96 Practical Aspects of Hematologic Stem Cell Harvesting and Mobilization97 Preclinical Process of Cell-Based Therapies98 Graft Engineering and Cell Processing99 Principles of Cell-Based Genetic Therapies100 Mesenchymal Stromal Cells101 T Cell Therapy of Hematological Diseases102 Natural Killer Cell-Based Therapies103 Dendritic Cell TherapiesPART X: Transplantation104 Overview of Hematopoietic Cell Transplantation105 Indications and Outcome of Allogeneic Hematopoietic Cell Transplantation for Hematologic Malignancies in Adults106 Unrelated Donor Hematopoietic Cell Transplantation107 Haploidentical Hematopoietic Cell Transplantation108 Unrelated Donor Cord Blood Transplantation for Hematologic Malignancies109 Graft-versus-Host Disease and Graft-versus-Leukemia Responses110 Complications After Hematopoietic Stem Cell TransplantationPART XI: Transfusion Medicine111 Human Blood Group Antigens and Antibodies112 Principles of Red Blood Cell Transfusion113 Principles of Platelet Transfusion Therapy114 Human Leukocyte Antigen and Human Neutrophil Antigen Systems115 Principles of Neutrophil (Granulocyte) Transfusions116 Principles of Plasma Transfusion: Plasma, Cryoprecipitate, Albumin, and Immunoglobulins117 Preparation of Plasma-Derived and Recombinant Human Plasma Proteins118 Transfusion Therapy for Coagulation Factor Deficiencies119 Hemapheresis120 Transfusion Reactions to Blood and Cell Therapy Products121 Transfusion-Transmitted Diseases122 Transfusion Medicine in Hematopoietic Stem Cell and Solid Organ Transplantation123 Pediatric Transfusion MedicinePART XII: Hemostasis and Thrombosis124 Overview of Hemostasis and Thrombosis125 The Blood Vessel Wall126 Megakaryocyte and Platelet Structure127 Molecular Basis for Platelet Function128 Molecular Basis of Blood Coagulation129 Regulatory Mechansims in Hemostasis130 Clinical Approach to the Patient with Bleeding or Bruising131 Laboratory Evaluation of Hemostatic and Thrombotic Disorders132 Acquired Disorders of Platelet Function133 Diseases of Platelet Number: Immune Thrombocytopenia, Neonatal Alloimmune Thrombocytopenia, and Posttransfusion Purpura134 Thrombocytopenia Caused by Platelet Destruction, Hypersplenism, or Hemodilution135 Heparin-Induced Thrombocytopenia136 Thrombotic Thrombocytopenic Purpura and the Hemolytic Uremic Syndrome137 Hemophilia A and B138 Inhibitors in Hemophilia A and B139 Rare Coagulation Factor Deficiencies140 Structure, Biology, and Genetics of von Willebrand Factor141 Disseminated Intravascular Coagulation142 Hypercoagulable States143 Antiphospholipid Syndrome144 Venous Thromboembolism145 Mechanical Interventions in Arterial and Venous Thrombosis146 Atherothrombosis147 Stroke148 Acute Coronary Syndromes149 Atrial Fibrillation150 Peripheral Artery Disease151 Antithrombotic Drugs152 Disorders of Coagulation in the NeonatePART XIII: Consultative Hematology153 Hematologic Changes in Pregnancy154 Hematologic Manifestations of Childhood Illness155 Hematologic Manifestations of Liver Disease156 Hematologic Manifestations of Systemic Disease: Renal Disease157 Hematologic Manifestations of Cancer158 Integrative Therapies in Patients with Hematologic Diseases159 Hematologic Manifestations of HIV/AIDS160 Hematologic Aspects of Parasitic Diseases161 Hematologic Problems in the Surgical Patient: Bleeding and Thrombosis162 The Spleen and Its Disorders163 Hematology in Aging164 (Online Only) Resources For The Hematologist: Interpretive Comments and Selected Reference Values for Neonatal, Pediatric, and Adult Populations
