Filarial parasites affect over 130 million people in tropical and subtropical regions of the world. They have a great impact on public health because of their often prolonged and sometimes debilitating effects, ranging from lymphatic inflammation and elephantiasis to skin disease and blindness. This symposium volume combines expertise from Western countries and areas where filariasis is endemic, and from disciplines as diverse as epidemiology and molecular biology. The contributors consider many aspects of the host-parasite interaction, including the pathological and immunological consequences of infection, and they discuss implications for the diagnosis and control of filarial disease. The book starts with an overview of lymphatic filariasis and onchocerciasis, epidemiological trends and problems, and the spectrum of clinical disease. The parasites themselves are then described, with emphasis on structural, biochemical and genetic features that may aid in strain and species identification and the development of new chemotherapeutic agents. Several papers focus on disease mechanisms, drawing on information from animal models and exploring the nature and pathogenetic significance of immune responses to human filarial infections, with reference to onchocercal antigens, antibody production and cell adherence reactions. Finally, antifilarial drugs, their mechanisms of action and reactions to treatment are reviewed. Throughout, constructive discussion highlights gaps in current knowledge and helps to identify priorities for future research.
Table of Contents
PARTIAL TABLE OF CONTENTS: Partial table of
Epidemiology of Lymphatic Filariasis (J. W.
Some Unsolved Problems in the Epidemiology of
Onchocerciasis (A. Southgate).
Clinical Responses in Human Onchocerciasis:
Parasitological and Immunological
Implications (C. D. Mackenzie et al.).
Scanning Electron Microscopy of Brugia Malayi
Dynamics of the Filarial Surface (R. E.
Characterization of the Filarial Genome (K-L.
Sim et al.).
Onchocerca Antigens in Protection, Diagnosis
and Pathology (M. E. Parkhouse et al.).
Cell Adherence to Microfilariae of Onchocerca
Volvulus: A Comparative Study (J. F. Williams
Regulation of Immune Responses in Lymphatic
Filariasis (W. F. Piessens et al.).
Humoral Immune Responses in Human
Onchocerciasis: Detection of Serum Antibodies
in Early Infections (N. Weiss & M. Karam).
Antibody Responses to Human Lymphatic
Filarial Parasites (R. M. Maizels).
Immunodiagnosis of Bancroftian Filariasis (S.
Dissanayake & M. M.
The Cat Infected with Brugia Pahangi as a
Model of Human Filariasis (D. A. Denham & C.
Primate Model for Onchocerciasis Research (B.
Ocular Lesions in Onchocerciasis.
Antifilarials and their Mode of Action (D.