Full Description
Pathophysiological Aspects of Proteases in Cancer provides a comprehensive overview of the multifaceted field of proteases in the cellular environment and focuses on the recently elucidated functions of complex proteolytic systems in physiology and pathophysiology. The book both gives insights on the general aspects of the role of proteases in cancer, their role as diagnostics and prognostics biomarkers, their impact on chemoresistance, and the future cutting-edge technologies like cocktail therapies and Cyber Knife technology. Given the breadth and depth of information covered in the respective contributions, the book will be immensely useful for researchers in oncology and working to identify targets for drug development.
Multidisciplinary in scope, the book bridges the gap between fundamental and translational research, with applications in the biomedical and pharmaceutical industry, making it a thought-provoking read for basic and applied scientists engaged in biomedical research.
Contents
Section I: General Aspects
1. Pathophysiological aspects of calpains in cancer
2. Mitochondrial proteases in cancer development and progression
3. Proteases in Head and Neck Cancer
4. Matrix metalloproteases and uveal melanomas
5. Proteases in DNA damage, repair and radio resistance: Cellular and Molecular aspects
6. Radiotherapy, proteases and gastric cancer: a complex interplay
7. Matrix metalloproteases in the pathogenesis of hepatocarcinoma
8. Exploring synthetic and natural compounds for Cathepsin B: Mechanisms and therapy
9. Kallikrein-related peptidase 3 (KLK3) as valuable biomarkers for prostate cancer
10. Ubiquitin -specific protease 3,7 in bone cancer and squamous cell carcinoma
11. Serine protease: structure, classification, mechanism and role in breast cancer
Section II: Proteases as Diagnostics and Prognostics Biomarkers
12. Protease activator receptor-1 and matrix metalloproteinase-1 as prognostic factors and novel therapeutic targets for gastric cancer
13. Matrix metalloproteases as diagnostic and prognostic biomarkers in cancer
14. From enzyme to predictors: Serine proteases in cancer diagnosis and prognosis
15. Cathepsins as a diagnostic and prognostic marker in Oral cancer
16. Role of Kallikreins in Prostate Cancer
17. Mechanistic aspects of Serine Protease as biomarkers in wound healing of lung cancer
18. The role of acetylcholinesterase in cancer development and possible therapeutic applications
19. Therapeutics of animal derived compounds in proteases induced cancer
20. Molecular Warriors: Proteases as Sentinels in the War Against Cancer Diagnosis and Prognosis
Section III: Proteases, Chemoresistance and Cancer
21. Serine proteases, chemoresistance and cancer
22. Cathepsins, chemoresistance and cancer
23. ix metalloproteases, chemoresistance and cancer
24. MMPs (-2 and -9) mediated drug resistance and their reversal in gynecological cancer
25. The link between trypsinogen and chymotrypsinogen in gastrointestinal cancer
26. Role of the proteasome in the development of chemoresistance in multiple myeloma
27. Role of cysteine cathepsin and matrix metalloproteases in progression and chemoresistance in ovarian and breast cancer
28. Proteases, chemoresistance and cancer
29. Breaking Barriers: Proteases as Key Players in Cancer Chemoresistance
Section IV: Other Aspects
30. Matrix metalloproteases-targeting low molecular weight compound
31. Synthetic protease inhibitors in oral, head and neck cancer: evidence from clinical trials.
32. Synthetic protease inhibitors in endocrine and gastroenterology cancers: results of clinical trials
33. Side effects of synthetic protease inhibitors used in gynecology cancers
34. Role of synthetic compounds with protease inhibitory activity in breast cancer
35. Cathepsin responsive nanomaterials for targeted delivery of malignant tumors
