Full Description
Emerging Modern Microfluidics Driven AutomationsDiscovery, Drug Delivery, Diagnostics, and Regulatory Concerns explores the fundamentals, applications and future direction of microfluidics in pharmaceutical science. The book discusses novel methodologies with diversified applications, especially in the theragnostic and biomedical arenas. Covering areas of modern microfluidics in drug discovery, drug delivery, diagnostics and regulatory concerns, the book has a special focus on the intellectual abilities of the process or product viability of microfluidics. Other topics include the applications of microfluidics for processing of biomaterials and nanomedicines, toxicological studies, disease/tumor 3D in vitro models, 3D printing of microfluidics, and personalized medicine applications. With contributions from authors in industry and academia, this resource is ideal for early-career pharmaceutical and biomedical engineering professionals involved in developing new tools for the delivery of therapeutics, novel drug discovery and medical diagnostics using Microfluidics technology.
Contents
Part I - Fundamentals 1. Introduction to microfluidics - physics, and applications 2. Fluid Dynamics in microfluidics 3. Microfluidic-assisted organic synthesis 4. Introduction to microfabrication and applications in biomedical sciences Part II - Applications in Drug Discovery 5. Microfluidics in cell culture systems 6. Single-cell screening using microfluidic systems 7. Microfluidic Vascular Networks for Engineered Tissues 8. Microscale Models of Inflammatory Diseases 9. Lab-on-a-chip techniques for high throughput proteomics and drug discovery 10. Organ-on-chip systems for personalized medicine 11. Antibody discovery using microfluidic systems Part III - Applications in Drug Delivery 12. Microfabrication and Microfluidic Devices for Drug Delivery 13. Microfluidic mixing and devices for preparing nanoparticulate drug delivery systems 14. Droplet-based microfluidics for cell encapsulation and delivery 15. Lab-on-a-chip synthesis of microparticles for drug encapsulation and controlled release 16. Microfluidic technologies for local drug delivery 17. Applications of microfluidics for processing of biomaterials and nanomedicines 18. 3D printing using microfluidics Part IV - Applications in Diagnostics 19. Introduction, structuring, and application of electrowetting Theory (EWOD) Microsystems in diagnostics 20. Introduction, structuring, and application of liquid dielectrophoresis in diagnostics. 21. Digital microfluidics technologies for diagnostic devices 22. Microfluidic devices for stem cell analysis 23. Development of immunoassays for protein analysis on nanobioarray chips 24. Applications of disease/tumour 3D in vitro models Part V- Intellectual and Regulatory Perspective 25. Current and future impact of microfluidic technology 26. Challenges to scaling up, commercialization, intellectual property, and regulatory issues
