Description
Immunotherapies for Neurologic Diseases, Volume 214 explores how neuroimmunotherapies intervene by targeting key molecules and pathways responsible for tissue damage in the central and peripheral nervous systems. The book details approved treatments that modulate T-cell signaling, antigen presentation, B cells and their trophic factors, autoantibodies, Fc receptors, complement, cytokines, and cell adhesion molecules. Each chapter includes clear explanations and illustrations, helping clinicians understand the mechanisms of these drugs in autoimmune neurological diseases. The volume serves as a practical and comprehensive guide, making complex therapeutic approaches accessible to medical professionals and students.The second section highlights the latest therapies for major autoimmune neurological diseases, offering step-by-step algorithms and escalation strategies for selecting optimal treatments. Controversies and uncertainties in therapy choices are discussed by leading experts, while additional chapters address emerging immunotherapeutic approaches for neurodegenerative diseases and the evolving concept of treating autoimmune pain. The book also covers practical applications of traditional immunosuppressants, IVIg, and targeted monoclonal antibodies, with dedicated chapters on conditions such as encephalitis, NMOSD, multiple sclerosis, and stiff person syndrome.- Summarizes and consolidates new research on immunotherapies for neurologic diseases- Identifies how immunotherapies work- Includes monoclonal antibodies or fusion proteins against B cells, T cells, and FcRn- Provides treatment algorithms and escalating therapies for common diseases- Highlights new agents in pipeline orin early trials
Table of Contents
1. Introduction to Neuroimmunotherapies: An impressive progress towards targeted effective biologicsSection 1. Special Invited Chapters: Evolution of Autoimmune Neurology2. Autoimmune encephalitis, Autoimmune dementias and Autoimmune psychotic disorders3. The History of Paraneoplastic Neurologic Disorders of the CNS, PNS, and Autonomic Nervous Systems: Perspective on the Past Towards a Brighter FutureSection 2. Basic principles of immune activation in neurological diseases as related to targeted immunotherapies4. Role of B cells and pathogenic autoantibodies in autoimmune CNS and PNS Neurologic diseases5. Role of complement in neurological autoimmunities: why need to target complement activation for effective immunotherapy6. Paraneoplastic autoimmune neurological disorders and role of immune checkpoint inhibitorsSection 3. Immunotherapeutic agents in Autoimmune Neurological Diseases: Current and evolving biologics7. The evolution and current status of anti-B cell therapies in autoimmune Neurologic diseases8. Evolving targeted biologics against T cells, cytokines and intracellular immune targets for multiple sclerosis with implications in other autoimmune neurological diseases9. FcRn inhibitors: a new era in neurotherapeutics10. Intravenous Immunoglobulin (IVIg) use in Neurology11. HSCT for Multiple sclerosis: Improving understanding and addressing misconceptions12. Autonomic nervous system autoimmunity and proposed immunotherapiesSection 4. Immunotherapies for specific Neurological Diseases (how do I do it): A step-by step approach based on evidence-based indications with a view to the future13. Immunotherapies on Autoimmune Encephalitis14. Immunotherapies in Relapsing-remitting Multiple sclerosis15. Immunotherapies in progressive Multiple sclerosis16. Disease Modifying Therapy in Pediatric Multiple Sclerosis17. Immunotherapies for neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD)18. Immunotherapies in Autoimmune Movement Disorders and Cerebellar Ataxia19. Immunobiology and Immunotherapies in Stiff-person syndrome and GAD antibody-spectrum disorders: Present and future therapeutic prospects20. Immunotherapies on Guillain-Barre syndrome and other Acute Autoimmune neuropathies21. Immunotherapies in CIDP and other Chronic Autoimmune Neuropathies22. Immunotherapy considerations for distal sensory-predominant and small fiber peripheral neuropathies23. Immunotherapies in Autoimmune neuromuscular Junction disorders: Acute and Chronic management24. Immunotherapies in Autoimmune Inflammatory Myopathies: Rationale and therapeutic updates25. The Future Unfolded: CAR T Cells and the Transformation of Treatment Algorithms in Autoimmune Neurology
