Description
DNA in Health, Identity and Ancestry examines the human genome and advances in molecular techniques in relation to their value in health, genetic ancestry, and forensic DNA. This book systematically presents these three areas, providing new insights into recent developments in these fields, including gene editing, ancestral fraction determination, and DNA profiling. It covers the latest advances in molecular biology to understand the pertinent issues in these areas. DNA in Health, Identity and Ancestry provides an introduction to human genomes, and then delves into health, forensics and ancestry across 36 chapters. Each section is concluded with practical case studies to demonstrate the application of the principles discussed in each respective section. This book is a valuable resource for researchers, practitioners, and postgraduate students in biochemistry, molecular biology and genetics. It not only provides them with fundamental knowledge on genetics, diseases, population genetics and forensic DNA, but also presents advances, technical operational standards, analytical tools and recent developments in these respective areas.- Offers a comprehensive understanding of genomes in relation to health, forensics, and ancestry- Provides detailed technical and operating standards, including for gene editing, genetic testing, ancestral fraction determination, DNA profiling, and ancient DNA analysis- Genome and advances in molecular techniques in relation to their value in medical genetics, ancestral fraction determinations, and forensic DNA
Table of Contents
1. Introduction to human genomes: nuclear and mitochondrial DNA2. Genetic Testing: A Biomedical, Social and Ethical Framework3. CRISPR/Cas9: The Future of Human Gene Editing4. Pharmacogenomics5. Infectious disease diagnosis via DNA analysis6. Donor and recipient matching for transfusion and transplantation surgery7. Circulating free DNA: history, applications, and promises8. Metagenomics of environmental samples9. DNA extraction methods for pathogen analysis10. Characterization and application of environmental DNA in multi-species biofilms11. TLE variants and immune thrombocytopenia susceptibility12. X-chromosome: Genetics, function and health.13. Food intolerance and coeliac disease in past human populations through DNA analysis14. Puzzling ABO Discrepancy Case Resolved Through Molecular Technique15. STR and mitochondrial DNA profiling for casework and paternity cases16. DNA databanking, hit matches and ethical issues17. Forensic parameters in Kedayan inferred using mtDNA data18. The application of dual mitochondrial markers for detecting porcine DNA in gelatine-containing processed food products19. DNA analysis of Elmina plane crash victims: a case study20. Archaeogenetics of human history21. Ancient DNA extraction and amplification techniques22. The usefulness of Y chromosome in the study of past populations23. Human migrations and settlements in Malay Archipelago24. Blood groups, HPA, HNA, cytokines and HLA-G: genetics and ancestry25. Ethnic-specific patterns of GSTM1 and GSTT1 in Malays, Chinese and Indians with specific comparison to Europeans26. The Archaeological Heritage of the Niah National Park's Caves Complex: History, Current Status, and Future Prospects27. The medical significance of human population genetics in southeast Asia and Oceania28. Genomic ancestry and health from mtDNA perspectives
