Description
The Handbook of Parkinson's Disease Mechanisms offers an integrated overview of the fundamental research devoted to understanding its causes and mechanisms, highlighting recent advances and clinical significance. With a strong focus on cellular and animal model studies, this book also examines the etiology, pathophysiology, epidemiology and underlying symptoms of Parkinson's disease.Written with an interdisciplinary approach, this book provides thorough research that will be of interest to researchers, clinicians and graduate students interested in neurodegenerative diseases.- Reviews etiology and pathophysiology of Parkinson's disease- Integrates clinical and fundamental research- Includes cellular, organoid, and animal models of PD- Discusses dopamine, neuroinflammation, lysosomal function, tau, Lewy bodies, gut-brain axis, and more
Table of Contents
1. Pathology, postmortem studies, neuromelanin2. PD epidemiology and PD economic burden3. Genetic influences and other causes4. Animal models for the study of PD etiology5. New cellular and organoid models for the study of PD6. Lewy bodies, Molecular Interactions of Lewy bodies in the brain7. Synaptophaty in PD; alpha-syn and tau relationship with PD8. Parkinson's disease as a synucleinopathy9. Lysosomal function and protein aggregation in PD10. Autophagy and mitophagy and neuropathological markers of familiar PD11. Mitochondrial dysfunction in PD12. The gut brain axis in PD13. Dopaminergic neurons susceptibility to degeneration / dysfunction of mitochondria, new PD models14. Neuroinflammation and microglia15. Extracellular space modifications and PD16. Dopamine neurotransmission in Parkinson's Disease17. Dopamine effects in striatal and subthalamic nucleus neurons18. Adaptations that follow partial and severe striatal dopaminergic denervation19. Molecular mechanisms underlying L-DOPA-induced dyskinesia, role of dopamine receptors20. Imaging and electrophysiology of direct and indirect pathway neurons in freely moving animals21. Striatal cholinergic system in PD22. Striatal serotoninergic system in PD23. Opto and chemogenetic studies on L-DOPA-induced dyskinesia24. Network dynamics in rodent PD and LID models25. Network dynamics in primate models and patients ; effects of DBS on network dynamics26. Mechanisms underlying impulse control disorders in PD27. Brain stem mechanism of PD symptoms
