Description
Transcriptomics in Atherosclerosis: Deciphering Molecular Signatures and Advancing Therapeutic Strategies integrates transcriptomic research and RNA-based therapeutics to understand and treat atherosclerosis. Emphasizing the power of genetic insights to revolutionize cardiovascular medicine, this book fills an essential gap by offering up-to-date insights into molecular mechanisms, diagnostic innovations, and therapeutic strategies, fostering a new era of personalized cardiovascular care. It addresses cutting-edge RNA sequencing methods, clinical translation, multi-omics integration, phenotyping, and treatment stratification, providing a holistic view of vascular pathology. Other important points include a focus on RNA-based biomarkers and therapeutics for early detection, monitoring, and targeted interventions in atherosclerosis.Readers will find advanced transcriptomic technologies, including single-cell and spatial transcriptomics, which unveil the complexities of atherosclerotic disease. The book promises to be a valuable resource for medical professionals seeking to deepen their knowledge in this burgeoning field.- Unravels the molecular intricacies of atherosclerosis using the latest transcriptomic technologies, offering new perspectives on disease mechanisms and potential therapeutic targets- Highlights the transformative potential of RNA molecules in advancing diagnostics and developing novel RNA-based treatments for personalized medicine in cardiovascular care- Provides actionable insights into translating transcriptomic findings into clinical applications, enhancing patient stratification and treatment strategies
Table of Contents
Section I – Introduction1. Atherosclerotic CVD – epidemiology and current challenges in management2. Atherosclerotic Plaque Phenotypes: Unraveling Complexity and HeterogeneitySection II – The role of RNAs in atherosclerosis progression and development3. Biogenesis and mechanisms of action of ncRNAs4. The role of ncRNA in plaque development and progression5. Signaling Pathways Regulating Gene Expression in Atherosclerosis6. Epitranscriptomics and Atherosclerosis:Section III – Transcriptomic Profiling of Atherosclerotic Lesions7. Essentials of Transcriptomic Methods: Navigating Through RNA Sequencing and Beyond8. Bridging the Gap in Transcriptomics: From Animal to Human Studies in Atherosclerosis9. Translating Transcriptomics into Clinical Practice: Utilizing Gene Expression Patterns for Advanced Patient Phenotyping and Stratification in Atherosclerosis Optimizing Study Design for In-depth Transcriptomic Analysis of Atherosclerotic Plaques10. Unveiling Sex-Specific Transcriptomic Mechanisms in AtherosclerosisSection IV – Integrating Multi-Omics Approaches in Atherosclerosis Research11. Combining Transcriptomics with Genomics, Proteomics, and Metabolomics12. Insights into Gene Regulatory Networks in Vascular Pathology13. Systems Biology and Network Analysis14. Use of artificial intelligence and machine learning for multi-omicsSection V – RNA-Based Theranostics: Revolutionizing Treatment and Diagnosis in Atherosclerotic Cardiovascular Disease15. RNA Therapeutics in Atherosclerosis:16. RNA Therapeutic Delivery Systems – advances and challenges17. Exploring Circulating RNAs: Emerging Biomarkers for Atherosclerosis Detection and MonitoringSection VI – Conclusion18. Future Directions and Emerging Technologies in Transcriptomic Research and Atherosclerosis
