Description
Transcriptomics in Atherosclerosis: Deciphering Molecular Signatures and Advancing Therapeutic Strategies explores how transcriptomic research is transforming our understanding and management of atherosclerosis. Bridging molecular biology and clinical medicine, it delves into the dynamic regulation of gene expression, the role of non-coding RNAs, and emerging insights from epitranscriptomics.The book emphasizes advanced technologies such as single-cell and spatial transcriptomics, while embracing systems-level integration with other omic layers. It highlights how these approaches can reveal disease mechanisms, refine risk stratification, and guide the development of RNA-based diagnostics and therapies.Designed for researchers, clinicians, and translational scientists, this volume moves beyond generic overviews to present current methods, practical insights, and real-world challenges in the field. By doing so, it lays the groundwork for a new generation of precision strategies in cardiovascular care.- Unravels the molecular complexity of atherosclerosis using the latest transcriptomic technologies, offering new perspectives on disease mechanisms and potential therapeutic targets- Highlights the transformative potential of RNA molecules in advancing diagnostics and developing novel RNA-based treatments for personalized medicine in cardiovascular care- Provides actionable insights into translating transcriptomic findings into clinical applications, enhancing patient stratification and treatment strategies
Table of Contents
Section I – Introduction1. Atherosclerotic CVD – epidemiology and current challenges in management2. Atherosclerotic Plaque Phenotypes: Unraveling Complexity and HeterogeneitySection II – The role of RNAs in atherosclerosis progression and development3. Biogenesis and mechanisms of action of ncRNAs4. The role of ncRNA in plaque development and progression5. Signaling Pathways Regulating Gene Expression in Atherosclerosis6. Epitranscriptomics and Atherosclerosis:Section III – Transcriptomic Profiling of Atherosclerotic Lesions7. Essentials of Transcriptomic Methods: Navigating Through RNA Sequencing and Beyond8. Bridging the Gap in Transcriptomics: From Animal to Human Studies in Atherosclerosis9. Translating Transcriptomics into Clinical Practice: Utilizing Gene Expression Patterns for Advanced Patient Phenotyping and Stratification in Atherosclerosis Optimizing Study Design for In-depth Transcriptomic Analysis of Atherosclerotic Plaques10. Unveiling Sex-Specific Transcriptomic Mechanisms in AtherosclerosisSection IV – Integrating Multi-Omics Approaches in Atherosclerosis Research11. Combining Transcriptomics with Genomics, Proteomics, and Metabolomics12. Insights into Gene Regulatory Networks in Vascular Pathology13. Systems Biology and Network Analysis14. Use of artificial intelligence and machine learning for multi-omicsSection V – RNA-Based Theranostics: Revolutionizing Treatment and Diagnosis in Atherosclerotic Cardiovascular Disease15. RNA Therapeutics in Atherosclerosis:16. RNA Therapeutic Delivery Systems – advances and challenges17. Exploring Circulating RNAs: Emerging Biomarkers for Atherosclerosis Detection and MonitoringSection VI – Conclusion18. Future Directions and Emerging Technologies in Transcriptomic Research and Atherosclerosis
