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Description
The book covers recent advances in the field of CNS therapeutics, including opportunities posed by expanding basic knowledge related to CNS conditions and novel approaches for efficient drug delivery to the brain (e.g., pharmaceutical nanocarriers and transporter- and transcytosis-mediated drug delivery to the brain inhibition of the blood-brain barrier). Chapters dealing with state-of-the-art in silico and in vitro tools for predictive purposes related to CNS bioavailability are also be included.
This is an ideal book for undergraduate students and graduates in the field of medicine and pharmaceutics, and professionals working in the field of brain disorders.
Table of Contents
Chapter 1- Transporter-mediated drug delivery to the brain.- Chapter 2 - Mechanisms and methods for evaluating drug delivery via transcytosis to the brain.- Chapter 3 -In vitro blood-brain studies.- Chapter 4 - In silico prediction of CNS bioavailability.- Chapter 5 - Use of unbound exposure data to establish in vitro-in vivo correlations for CNS drug candidates.- Chapter 6 - Intranasal Delivery of Drugs to the Central Nervous System.- Chapter 7 - Polymeric nanoparticles for nose-to-brain delivery in Alzheimer's and Parkinson´s diseases.- Chapter 8 - Barriers of the CNS and their contribution to drug-resistant epilepsy.- Chapter 9 - Network-pharmacology and central nervous system drug development.
