Advances in Prodrugs : Design and Therapeutic Applications

著者名：Trandafir Supuran, Claudiu (EDT)/Angeli, Andrea (EDT)/Tanini, Damiano (EDT)

Elsevier（2024/10/01発売）

• 言語：ENG
• ISBN：9780443156359
• eISBN：9780443156342

Description

Advances in Prodrugs: Design and Therapeutic Applications provides a versatile tool in prodrug design and development as well as a concrete perspective on clinical and preclinical studies currently available on prodrugs. The first part of this book discusses different chemical classes of prodrugs, with particular emphasis on metabolic pathways and mechanisms involved in the activation of their functional groups. The second part of the book covers therapeutic applications of prodrugs against the most discussed diseases, providing detailed discussion on recent achievements in the field. This book offers researchers involved in drug discovery key criteria for the successful development of prodrug-based therapeutic tools.Prodrugs are inactive drug precursors which undergo different chemical transformation by metabolic processes to provide pharmacologically active compounds. Prodrugs include a broad range of structurally diverse molecules employed for the treatment of several diseases.- Highlights chemistry and pharmacology-related aspects, offering a versatile tool for readers involved in prodrug development and study- Discusses in-depth treatment of several activation mechanisms and applications for disease treatments- Covers a range of topics from basic contents, design, and mechanisms of actions to current applications in drugs

Table of Contents

PART I: INTRODUCTION1. PRODRUGS: GENERAL CONCEPTS, PRODRUG DESIGN IN MEDICINAL CHEMISTRYAndrea Angeli, Claudiu T. Supuran and Damiano TaniniPART II: ACTIVATION MECHANISMS AND RELATED FUNCTIONAL GROUPS2. pH-SENSITIVE PRODRUGSEmanuela Berrino3. ENZYME-MEDIATED ACTIVATION OF PRODRUGSSimone Carradori, Ilaria D'Agostino and Concettina La Motta4. REACTIVE OXYGEN SPECIES-RESPONSIVE PRODRUGSJean-Yves Winum5. PHOTOACTIVABLE PRODRUGSDamiano Tanini6. ANTIBODY DIRECTED ENZYME PRODRUG THERAPY (ADEPT)Paolo Rovero, Andrea Di Santo and Anna Maria Papini7. SELF-ASSEMBLING PRODRUGSMariana Pinteala V8. PRODRUG-BASED NANOMEDICINES: A SUCCESSFUL RATIONALE TO DESIGN NOVEL AND EFFECTIVE DELIVERY STRATEGIESGiulia Vanti9. HYPOXIA-ACTIVATED PRODRUGSWagdy M. EldehnaPART III: APPLICATION OF PRODRUGS IN THE TREATMENT OF DISEASES10. ANTIVIRAL AND ANTIRETROVIRAL PRODRUGSClaudiu T. Supuran and Luigi Pisano11. PRODRUGS FOR CANCER THERAPYAndrea Angeli12. PRODRUGS FOR NEURODEGENERATIVE DISEASESPaolo Guglielmi, Arianna Granese, Daniela Secci and Paola Chimenti13. PRODRUGS IN CARDIOVASCULAR THERAPYLaura Fumagalli and Angelica Artasensi14. PRODRUGS FOR OCULAR DISEASESAlessio Nocentini15. ANTIBACTERIAL PRODRUGSRaivis Žalubovskis16. PRODRUGS AGAINST NEGLECTED DISEASESALANE BEATRIZ VERMELHO