Description
**Selected for 2025 Doody's Core Titles® with "Essential Purchase" designation in Rheumatology**With its comprehensive, global coverage of all aspects of diagnosis, screening, and treatment in both adults and children, Firestein & Kelley's Textbook of Rheumatology remains your reference of choice in this evolving field. The fully revised 12th Edition retains the user-friendly, full color format, providing in-depth guidance in rheumatology with an ideal balance of basic science and clinical application. New editors, new chapters, and new illustrations keep you fully up to date on recent advances in genetics and the microbiome, current therapies, and other rapid changes in the field.- Covers everything from basic science, immunology, anatomy, and physiology to diagnostic tests, procedures, physical examination, and disease pathogenesis, manifestations and treatment―including key data on outcomes to better inform clinical decision making- Includes new or significantly revised chapters on Pre-Clinical Autoimmunity; The Microbiome in Health and Disease; Physical Therapy and Rehabilitation; Nutrition and Rheumatic Disease; Classification and Epidemiology of Spondyloarthritis; Etiology and Pathogenesis of Osteoarthritis; COVID and Rheumatic Disease; Vaccination in Rheumatic Disease; Autoimmune Complications of Immune Checkpoint Inhibitors for Cancer; and many more- Features 1,200 high-quality illustrations, including superb line art, quick-reference tables, and full-color clinical photographs; many new illustrations highlight diseases among racially diverse patients- Shares the knowledge and expertise of internationally renowned scientists and clinicians, including new editors Drs. Ted Mikuls and Tuhina Neogi- Demonstrates the complete musculoskeletal exam in online videos, including abnormal findings and the arthroscopic presentation of diseased joints
Table of Contents
PART 1 Structure and Function of Bone, Joints, and Connective Tissue1 Developmental Biology, Organization, and Function of the Synovial Joints2 Synovium3 Cartilage and Chondrocytes4 Development and Biology of Bone5 Muscle Anatomy, Physiology, and Biochemistry6 Biomechanics7 Regenerative Medicine and Tissue Engineering8 Proteinases and Matrix DegradationPART 2 Cells Involved in Autoimmune Diseases and Inflammation9 Dendritic Cells10 Mononuclear Phagocytes11 Neutrophils12 T Lymphocytes13 B Cells14 Fibroblasts andFibroblast-like Synoviocytes15 Mast Cells and Basophils16 Innate Lymphoid Cells and Natural Killer Cells17 Platelets and MegakaryocytesPART 3 Effector Mechanisms in Autoimmunity and Inflammation 18 Principles of Signaling19 Innate Immunity20 Adaptive Immunity21 Immune Tolerance and Autoimmunity22 Pre-clinical Autoimmunity23 The Microbiome in Rheumatic Diseases24 Genetics of Rheumatic Diseases25 Epigenetics of Rheumatic Diseases26 Complement System27 Prostaglandins, Leukotrienes, and Related Compounds28 Angiogenesis29 Cytokines and Chemokines30 Neuronal Mechanisms of Pain and InflammationPART 4 Broad Issues in the Approach to Rheumatic Disease31 Clinical Research Methods in the Rheumatic Diseases32 Epidemiology and Impact of Rheumatic Diseases33 Assessment of Health Outcomes34 Biomarkers in Rheumatology35 Occupational, Environmental, and Recreational Musculoskeletal Disorders36 Cardiovascular Risk in Inflammatory Rheumatic Disease37 Cancer Risk in Rheumatic Diseases38 Occupational Therapy, Physical Therapy, and Rehabilitation39 General Principles of Pregnancy and Rheumatic Disease: Pre-pregnancy AssessmentPART 5 Evaluation of Generalized and Localized Symptoms40 History and Physical Examination of the Musculoskeletal System41 Ultrasound in Rheumatology42 Evaluation of Monoarticular and Polyarticular Arthritis43 Skin and Rheumatic Diseases44 The Eye and Rheumatic DiseasesPART 6 Differential Diagnosis of Regional and Diffuse Musculoskeletal Pain45 Neck Pain46 Shoulder Pain47 Low Back Pain48 Hip and Knee Pain49 Foot and Ankle Pain50 Hand and Wrist Pain51 Temporomandibular Joint Disorders52 FibromyalgiaPART 7 Diagnostic Tests and Procedures in Rheumatic Diseases53 Synovial Fluid Analyses, Synovial Biopsy, and Synovial Pathology54 Arthrocentesis and Injection of Joints and Soft Tissues55 Anti-nuclear Antibodies56 Autoantibodies in Rheumatoid Arthritis57 Acute Phase Reactants58 Imaging in Rheumatic DiseasesPART 8 Pharmacology of Anti-rheumatic Drugs59 Therapeutic Targeting of Prostanoids60 Glucocorticoid Therapy61 Traditional DMARDs: Methotrexate, Leflunomide, Sulfasalazine, Hydroxychloroquine, and Combination Therapies62 Immunosuppressive Drugs63 Anti-cytokine Biologics64 Cell-Targeted Biologics and Emerging Targets: Rituximab, Abatacept, and Other Biologics65 Janus Kinase and Other Intra-cellular Targets66 Urate-Lowering Therapy67 Bisphosphonates68 Analgesic Agents in Rheumatic Disease69 Nutrition and Rheumatic DiseasesPART 9 Rheumatoid Arthritis and Sjögren's Syndrome70 Etiology of Rheumatoid Arthritis71 Pathogenesis of Rheumatoid Arthritis72 Clinical Features of Rheumatoid Arthritis73 Treatment of Rheumatoid Arthritis74 Sjögren's SyndromePART 10 Spondyloarthritis75 Classification and Epidemiology of Spondyloarthritis76 Axial Spondyloarthritis77 Reactive Arthritis78 Psoriatic Arthritis79 Inflammatory Bowel Disease–Associated Arthritis and Other Enteropathic ArthropathiesPART 11 Systemic Lupus Erythematosus and Related Syndromes80 Etiology and Pathogenesis of Systemic Lupus Erythematosus81 Clinical Features of Systemic Lupus Erythematosus82 Treatment of Systemic Lupus Erythematosus83 Antiphospholipid SyndromePART 12 Systemic Sclerosis, Inflammatory Myopathies, and Overlap Syndromes84 Etiology and Pathogenesis of Systemic Sclerosis85 Clinical Features and Treatment of Scleroderma86 Inflammatory Diseases of Muscle and Other Myopathies87 Overlap SyndromesPART 13 Vasculitis88 Classification and Epidemiology of Systemic Va
