Description
Regulatory T cells and Autoimmune Diseases addresses recent findings concerning the role of Tregs in the pathogenesis of autoimmune diseases as well as their therapeutic aspects. In particular, this book deals with the various Treg based mechanisms which can lead to autoimmune diseases and covers the different aspects of linking Tregs with autoimmune mechanisms involved in disease development by discussing animal models and human studies.The book specifically focuses on the Treg based therapeutics and their targets to manage all known autoimmune rheumatic, central nervous system, bowel, liver, thyroid, kidney, myopathic, skin, blood & blood vessel, and eye diseases and aims to provide a must-have reference for designing therapeutic strategies to treat these autoimmune diseases. Additionally, the book covers the vaccines induced effects on functioning of Tregs and development of CAR Tregs therapy for these autoimmune diseases and concludes with current challenges and future prospects of Treg-based therapeutics. It is carefully designed to meet the requirements of both basic and advanced researchers in the area and give new dimensions and insight into the regulatory T cells' role in autoimmune disease pathogenesis and therapeutic aspects.- Brings the reader up-to-date on the mechanisms of regulatory T cells (Tregs) in pathogenesis and therapeutics of all autoimmune diseases known to date- Provides explicit color illustrations and comprehensible tables for explaining the mechanistic aspects and emerging information in the field- Includes human clinical trials and animal model studies for Tregs in diverse autoimmune diseases for the mitigation of the symptoms of autoimmune diseases- Offers scientifically applicable and relevant content for readers of various disciplines, including biomedical sciences, medical microbiology/biotechnology, immunology, and medicine
Table of Contents
Part I Regulatory T cells and immune system 1. Regulatory T cells and their functions in immune system 2. Regulatory T cells: mechanisms of action 3. Regulatory T cells and autoimmunity 4. Sex differences in regulatory T cells during autoimmune disease Part II Role of regulatory T cells in rheumatic diseases 5. Role of regulatory T cells in pathogenesis and therapeutics of systemic lupus erythematosus 6. Role of regulatory T cells in the pathogenesis and therapeutics of primary Sjögren's syndrome 7. Role of regulatory T cells in pathogenesis and therapeutics of rheumatoid arthritis and juvenile idiopathic arthritis 8. Role of regulatory T cells in pathogenesis and therapeutics of psoriatic arthritis 9. Role of regulatory T cells in pathogenesis and therapeutics of spondyloarthritis 10. Role of regulatory T cells in pathogenesis and therapeutics of ankylosing spondylitis Part III Role of regulatory T cells in central nervous system demyelinating autoimmune diseases 11. Role of regulatory T cells in pathogenesis and therapeutics of multiple sclerosis 12. Role of regulatory T cells in the pathogenesis and therapeutics of neuromyelitis optica spectrum disorder Part IV Role of regulatory T cells in peripheral nerve, muscle and neuromuscular autoimmune diseases 13. Role of regulatory T cells in pathogenesis and therapeutics of myasthenia gravis 14. Role of regulatory T cells in pathogenesis and therapeutics of GuillainBarré syndrome and experimental autoimmune neuritis 15. Role of regulatory T cells in pathogenesis and therapeutics of chronic inflammatory demyelinating polyradiculoneuropathy 16. Role of regulatory T cells in pathogenesis and therapeutics of dermatomyositis and polymyositis Part V Role of regulatory T cells in inflammatory bowel diseases 17. Role of regulatory T cells in pathogenesis and therapeutics of Crohn's disease and ulcerative colitis 18. Role of regulatory T cells in pathogenesis and therapeutics of celiac disease Part VI Role of regulatory T cells in autoimmune liver diseases 19. Role of regulatory T cells in the pathogenesis and therapeutics of autoimmune hepatitis 20. Role of regulatory T cells in pathogenesis and therapeutics of primary biliary cholangitis and primary sclerosing cholangitis Part VII Role of regulatory T cells in autoimmune thyroid diseases 21. Role of regulatory T cells in pathogenesis and therapeutics of Hashimoto's thyroiditis 22. Role of regulatory T cells in pathogenesis and therapeutics of Graves' disease and Graves' orbitopathy Part VIII Role of regulatory T cells in autoimmune lung and kidney diseases 23. Role of regulatory T cells in pathogenesis and therapeutics of Goodpasture's syndrome (anti-glomerular basement membrane disease) 24. Role of regulatory T cells in pathogenesis and therapeutics of autoimmune glomerulonephritis (IgA vasculitis and IgA nephropathy) Part IX Role of regulatory T cells in autoimmune skin diseases 25. Role of regulatory T cells in pathogenesis and therapeutics of vitiligo 26. Role of regulatory T cells in pathogenesis and therapeutics of psoriasis 27. Role of regulatory T cells in pathogenesis and therapeutics of atopic dermatitis 28. Role of regulatory T cells in pathogenesis and therapeutics of alopecia areata 29. Role of regulatory T cells in pathogenesis and therapeutics of pemphigus vulgaris and bullous pemphigoid 30. Role of regulatory T cells in pathogenesis and therapeutics of scleroderma (systemic sclerosis) Part X Role of regulatory T cells in autoimmune blood and blood vessel disorders 31. Role of regulatory T cells in pathogenesis and therapeutics of primary antiphospholipid syndrome (Hughes syndrome) 32. Role of regulatory T cells in pathogenesis and therapeutics of Kawasaki disease 33. Role of regulatory T cells in pathogenesis and therapeutics of Behçet disease 34. Role of regulatory T cells in pathogenesis and therapeutics of immune thrombocytopenia 35.
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