Description
This book covers fundamental aspects in the preparation of polymeric in-situ, stimuli-responsive hydrogels; the properties, characterization, chemistry, and fabrication of these hydrogels is detailed, helping the reader to select the most appropriate material and design for the desired application. The book goes on to review applications in ophthalmic drug delivery, covering in vitro and in vivo models, animal models, preclinical testing, patents and more. Stimuli-responsive Hydrogels for Ophthalmic Drug Delivery is a must-have reference for researchers and academics in the fields of materials science, biomaterials, pharmacology and polymer science, with an interest in clinical aspects of hydrogel design and application.- Provides step-by-step coverage for engineering in-situ and stimuli-responsive hydrogels, from design, characterization, and toxicity considerations to fabrication, process optimization, and drug release kinetics- Utilizes an interdisciplinary approach, bringing together authors from pharmacology, polymer science, and medical backgrounds- Details the advantages and challenges of using stimuli-responsive hydrogels for ophthalmic drug delivery, with a focus on clinical translation
Table of Contents
Part I: Properties and Preparation1. Introduction to polymeric in-situ forming hydrogels2. Biopolymers for in-situ forming hydrogels: synthesis, characterization, and toxicity3. Chemistry and applications of biopolymer stimuli-responsive in-situ gels4. Design, engineering, and fabrication of biopolymer in-situ forming hydrogels5. Process optimization for design and fabrication of biopolymer stimuli-responsivehydrogels6. Properties of biopolymeric in-situ hydrogels7. Swelling and drug release kinetics of biopolymer in-situ forming hydrogels8. Structural and load-bearing characteristics of biopolymer in-situ forming hydrogels9. Functionalization of in-situ forming biopolymer hydrogelsPart II: Applications in Ophthalmic Drug Delivery10. Eye anatomy, physiology, and ocular barriers11. In vitro and in vivo models in ophthalmic drug delivery12. Formulation and ocular drug delivery routes13. Clinical indications of stimuli-responsive hydrogels in ophthalmic drug delivery14. Natural and synthetic materials for stimuli-responsive hydrogels in ophthalmic drug delivery15. Characteristics and kinetics of in-situ forming hydrogels in ophthalmic drug delivery16. Cell-laden stimuli-responsive hydrogels in ophthalmic drug delivery17. Animal models and preclinical tests for evaluation of stimuli-responsive hydrogels in ophthalmic drug delivery18. Biopolymer-based in-situ forming hydrogels: from laboratory to practical application19. Commercially available stimuli-responsive hydrogels for ophthalmic drug delivery20. Advantages and challenges of biopolymer in-situ hydrogels for ophthalmic drug delivery21. Patents for biopolymer in-situ hydrogels for ophthalmic drug delivery
