幹細胞：COVID-19とサイトカイン・ストームの代替療法 Stem Cells : An Alternative Therapy for COVID-19 and Cytokine Storm

著者名：Verma PhD, Yogesh Kumar (EDT)/Satija, Neeraj Kumar (EDT)/Raghav PhD, Pawan Kumar (EDT)/Tyagi, Nishant (EDT)/Kumar, Subodh (EDT)

Academic Press（2023/11/29発売）

• 言語：ENG
• ISBN：9780323955454
• eISBN：9780323955461

Description

Stem Cells: An Alternative Therapy for COVID-19 and Cytokine Storm provides mechanistic insights into the role of stem cells to combat COVID-19 outbreak and other pathologies where cytokines storm is the cause of concern for e.g., radiation exposure, multiple organ failure and sepsis. There has been an increase in number of cases of new diseases in the last decade, including mucormycosis, Zika virus, H1N1 influenza virus, among others. These diseases can be characterized by the induction of cytokine storm, which is mainly responsible for morbidity and mortality.Stem cell therapy has emerged as a potential treatment for viral diseases, including, but not limited to, COVID-19. Interestingly, clinical trials in patients with COVID-19 complications depicted faster recovery in patients post mesenchymal stem cells therapy owing to the decreased cytokines levels, anti-viral effects and regeneration of the infected tissue.- Evaluates the role of MSCs to combat cytokine storm, the challenges regarding COVID-19 therapy and how they can be countered using stem cells, and the risk of opportunistic infections post COVID-19- Presents how stem cell therapy has emerged as a potential treatment for viral diseases, including, but not limited to, COVID-19- Provides a detailed understanding of the novel coronavirus, with an emphasis on therapeutic aspects

Table of Contents

- Targets of SARS-CoV-2: Therapeutic Implications for COVID-19- COVID-19 Biology: Cytokine Storms and Their Implications- Comparative Clinical Investigation of Blood Profiling in COVID-19 Patients- SARS-CoV-2 Associated Complications- COVID-19 Diagnostic Approaches and Modern Mesenchymal Stem Cell-based Treatment- Modulation of Pentose Phosphate Pathway Augments the Efficacy of 2-deoxy-D-glucose in COVID-19 Management- Therapeutic Landscape of SARS-CoV-2- Pharmacotherapeutics for Cytokine Storm in COVID-19- Clinical Investigation of COVID-19 Prevention and Treatment- Potential Therapeutic Landscape of COVID-19: Molecular Targets, Repurposed Drugs, and Nano- and Cell-based Intervention- Medical Care for SARS-CoV-2- Therapeutic Approaches for Opportunistic Infection Post-COVID-19- Focusing on the Cytokine Storm in the Battle Against COVID-19: The Rising Role of Mesenchymal-derived Stem Cells- Cytokine Storm in COVID-19 and Other Diseases: Emerging Therapeutic Interventions- Stem Cells as Therapeutics and Their Implications in Cytokine Storm in COVID-19- Visualizing Chemical Functionality and Structural Insights into SARS-CoV-2 Proteins- Mesenchymal Stromal Cells and Pleiotropic Therapeutic Advantages in COVID-19 Management- Mesenchymal Stem Cells - Role in Tuberculosis Pathogenesis and Persistence- Radiosensitivity of Cancer Stem Cells Holds Promise for the Outcome in Radiotherapy and COVID-19 Infections- Immunomodulatory Therapeutic Potential of Mesenchymal Stem Cells in COVID-19 Pathogenesis- Clinical Limitations of Stem Cell Therapy- Clinical Limitations in Stem Cell Therapy- Stem Cell Based Products and the Regulatory Hurdle Race- Implications of Stem Cell Therapy on the Socio-Scientific Community