Description
**Selected for Doody's Core Titles® 2024 in Clinical Genetics**Psychiatric Genomics presents and synthesizes available knowledge in the field of psychiatric genomics, offering methodologies to advance new research and aid clinical translation. After providing an introduction to genomics and psychiatry, international experts discuss the genomic basis of schizophrenia, bipolar disorder, depression, personality disorders, anxiety disorders, addictions, eating disorders, and sleep disorders, among other disorders. In addition, recommendations for next steps in clinical implementation and drug discovery are discussed in-depth, with chapters dedicated to pharmacogenomics and antipsychotics, antidepressants and mood stabilizers, adverse drug reactions, implementation of pharmacogenomics in psychiatric clinics, and ethical issues.Finally, methods sections provide a solid grounding in research approaches and computational analytics, from using animal models in psychiatric genomics and accessing biobanks, to employing computational analysis, genome-wide association studies (GWAS), brain pathophysiology, and endophenotypes in psychiatric research.- Thoroughly examines the genetic mechanisms underlying a broad range of psychiatric disorders- Offers genomic methodologies and analytical approaches supporting new research and clinical translation, including personalized diagnosis and treatment models- Features chapter contributions from international leaders in the field
Table of Contents
1. Genomics and psychiatry: a historical overview2. Schizophrenia genomics3. Genetics of bipolar disorder4. Genetics of depression5. Genetics of personality disorders6. Genomics and epigenomics of anxiety and obsessive-compulsive disorders7. Neurogenetics of alcohol use disorder a subset of reward deficiency syndrome: candidate genes to be or not to be?8. Pharmacogenomics and antipsychotics: efficacy and adverse drug reactions9. Pharmacogenomics and antidepressants: efficacy and adverse drug reactions10. Pharmacogenomics and mood stabilizers: efficacy and adverse drug reactions11. Balancing prevention and respect: the ethical stakes of a psychiatric genomics lens for mental disorder and intellectual disability12. Genetic animal models for psychiatric disorders13. Psychiatric genomics: brain pathophysiology and genetic factors14. Integration with systems biology approaches and -omics data to characterize risk variation15. Usage of biobank data for psychiatric genomics and promotion of precision psychiatry16. Shared heritability among psychiatric disorders and traits17. Endophenotypes in psychiatric genomics: a selective review of their status and a call to action
