Description
**Selected for Doody's Core Titles® 2024 in Pharmacology**Atkinson's Principles of Clinical Pharmacology, Fourth Edition is the essential reference on the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development. This well-regarded survey continues to focus on the basics of clinical pharmacology for the development, evaluation and clinical use of pharmaceutical products while also addressing the most recent advances in the field. Written by leading experts in academia, industry, clinical and regulatory settings, the fourth edition has been thoroughly updated to provide readers with an ideal reference on the wide range of important topics impacting clinical pharmacology.- Presents the essential knowledge for effective practice of clinical pharmacology- Includes a new chapter and extended discussion on the role of personalized and precision medicine in clinical pharmacology- Offers an extensive regulatory section that addresses US and international issues and guidelines- Provides extended coverage of earlier chapters on transporters, pharmacogenetics and biomarkers, along with further discussion on "Phase 0" studies (microdosing) and PBPK
Table of Contents
1. Introduction to Clinical PharmacologyArthur John Atkinson Jr., Juan J. L. Lertora and Shiew Mei Huang2. Clinical PharmacokineticsArthur John Atkinson Jr.3. Compartmental Analysis of Drug DistributionArthur John Atkinson Jr.4. Drug Absorption and BioavailabilityArthur John Atkinson Jr.5. Effect of Renal Disease on PharmacokineticsThomas D. Nolin, Albert Dreisbach and Juan J. L. Lertora6. Pharmacokinetics in Patients Requiring Renal Replacement TherapyArthur John Atkinson Jr., Thomas D. Nolin and John Allen7. Effect of Liver Disease on PharmacokineticsJuan J. L. Lertora, Robert A. Branch and Nathalie K. Zgheib8. Non-Compartmental and Compartmental Approaches to Pharmacokinetic Data AnalysisPaolo Vicini9. Population PharmacokineticsRaymond Miller and Ophelia Yin10. Pathways of Drug MetabolismNina Isoherranen and R. Scott Obach11. Methods of Analysis of Drugs and Drug MetabolitesMark Edward Arnold and Brian Booth12. Clinical PharmacogenomicsAnuradha Ramamoorthy, Tristan Sissung and Michael Pacanowski13. Mechanisms and genetics of drug transportLei Zhang, Sook Wah Yee, Osatohanmwen Enogieru, Shiew Mei Huang and Kathleen Giacomini14. drug-drug interactionsAleksandra Galetin, Lei Zhang, A. David Rodrigues and Shiew Mei Huang15. Biochemical Mechanisms of Drug ToxicityArthur John Atkinson Jr., Jack Uetrecht, Denis M. Grant and Peter G. Wells16. pharmacogenomic mechanisms of drug toxicityShiew Mei Huang, Ligong Chen and Kathleen Giacomini17. Biomarkers in Drug DevelopmentRobert N. Schuck, Jana G. Delfino, Christopher Leptak and John A. Wagner18. imaging in drug developmentOwen Carmichael19. dose-effect and concentration-effect analysisJuan J. L. Lertora, Yaning Wang, Jiang Liu and Justin C. Earp20. time course of drug responseNick Holford21. disease progress modelsDiane Renee Mould, Nick Holford and Carl Peck22. Pharmacological Differences between Men and WomenMary F. Paine and Karen Dinh Vo23. drug therapy in pregnant and nursing womenCatherine Stika and Marilynn C. Frederiksen24. pediatric clinical pharmacology and therapeuticsBridgette Jones, John N. van den Anker, Gilbert J. Burckart and Gregory Kearns25. Medication Therapy in Older AdultsS. W. Johnny Lau, Danijela Gnjidic and Darrell Abernethy26. clinical analysis of adverse drug reactionsChristine Chamberlain, Cindy Kortepeter and Monica Munoz27. Quality Assessment of Drug TherapyCharles Edward Daniels28. portfolio and project planning and management in the drug discovery evaluation, development, and regulatory review processCharles V. Grudzinskas, Michael Dyszel, Khushboo Sharma and Charles T. Gombar29. Drug DiscoveryThomas Bateman30. Non-Clinical Drug DevelopmentChris H. Takimoto31. pre-clinical prediction of human pharmacokineticsMalcolm Rowland32. Phase I Clinical StudiesRobert Joseph Noveck and Martina D. Sahre33. pharmacokinetic and pharmacodynamic considerations in the development of biotechnology products and large moleculesPamela Garzone and Yow-Ming C. Wang34. Design of Clinical Development ProgramsMegan Gibbs, Bengt Hamren, Helen Tomkinson, Renee Bailey Iacona and David Boulton35. the role of the FDA in guiding drug development;Elimika Pfuma Fletcher, Rajanikanth Madabushi, Chandrahas Sahajwalla, Lawrence J. Lesko and Shiew Mei Huang36. Emerging Clinical Pharmacology Topics in Drug Development and Precision MedicineQi Liu, Jack A. Gilbert, Hao Zhu, Shiew Mei Huang, Elizabeth Kunkoski, Promi Das, Kimberly Bergman, Mary Buschmann and M Khair ElZarradAppendix IAppendix II
