Description
Sirtuin Biology in Medicine: Targeting New Avenues of Care in Development, Aging, and Disease provides a fascinating and in-depth analysis of sirtuins in the body during normal physiology as well during disease highlighting the targeting of sirtuin-controlled pathways for the development of innovative, efficacious, and safe therapeutic strategies for multiple disorders in the body that ultimately can affect lifespan extension. Sirtuins are expressed throughout the body, have broad biological effects, and can significantly impact both cellular survival and longevity during acute and long-term illnesses. These histone deacetylases play an intricate role in the pathology, progression, and treatment of several disease entities ranging from neurodegenerative disorders, cardiovascular disease, immune system dysfunction, reproductive dysfunction, endocrine disorders, gastrointestinal disease, drug dependency, and aging-related disorders. Implementing a translational medicine format, this unique reference highlights novel signaling pathways for sirtuins that promote stem cell proliferation, enhance cellular protection, modulate pathways of apoptosis and autophagy, and extend life span. Each chapter is presented with insightful detail that will be of interest and a comprehensive resource to audiences that include scientists, physicians, pharmaceutical industry experts, nutritionists, and students.- Chapters are authored by internationally recognized experts who discuss the broad role of sirtuins in health and disease- Details the basic and clinical role of sirtuins for the development of new clinical treatments- Summarizes the multidiscipline views and publications for the compelling discipline of sirtuins by covering systems throughout the body- Serves as an important resource for a broad audience of healthcare providers, scientists, drug developers, and students in both clinical and research settings
Table of Contents
Section I: Sirtuins, neurodegenerative disease, lifespan extension, and aging 1. Novel treatment strategies for neurodegenerative disease with sirtuinsKenneth Maiese 2. NAD1: a crucial regulator of sirtuin activity in agingNady Braidy And Maria Villalva (D.) 3. Sirtuins and life span extensionShin-Hae Lee and Kyung-Jin Min 4. Sirtuins and agingBrian J. Morris 5. Sirtuins in the biology of agingMateusz Wątroba And Dariusz Szukiewicz 6. Sirtuins as regulators and the regulated molecules of exosomesQing Han, Yirui Cheng, and Weiliang Xia 7. Sirtuins in aging, age-related pathologies and their association with circadian rhythmSankarathi Balaiya 8. Sirtuins, mitochondria, and the melatonergic pathway in Alzheimer's diseaseG. Anderson and M. Maes 9. Sirtuins, melatonin, and the relevancevof circadian oscillatorsRüdiger Hardeland10. Epigenetic role of sirtuins in neurodegenerative brain disordersArchita Khanna, Anamika, and Surendra Kumar Trigun 11. Sirtuins and stem cell maintenance, proliferation, and differentiationRyan A. Denu and Peiman Hematti 12. Sirtuins in mechanistic target of rapamycin complex 1 signalingJ. Burillo, P. Marqués, B. Jiménez, C. González-Blanco, M. Benito, and C. Guillén 13. Free-radical redox timer, sirtuins and aging: from chemistry of free radicals to systems theory of reliabilityVitaly K. Koltover and Tatjana A. Skipa 14. Sirtuins, mitochondria, and exercise in health and diseaseAnibh M. Das and Partha DabkeSection II: Sirtuins, cardiovascular disease and end-organ disease 15. Scope to develop sirtuins modulators as a therapy to attenuate cardiac complicationsBugga Paramesha and Sanjay K. Banerjee 16. Role of sirtuins in cardiovascular diseasesVenkatraman Ravi, Sneha Mishra, and Nagalingam Ravi Sundaresan17. Targeting sirtuins to modulate energy metabolism in heart diseaseTsunehisa Yamamoto and Ken Shinmura 18. Sirtuin 1 mediates hepatoprotective effects of resveratrol-like compounds in experimental liver injuryHassan Farghali, Mighty Kgalalelo Kemelo, and Nikolina Kutinová Canová 19. Sirtuins as key players in aging and kidney dysfunctionLuca Perico and Ariela Benigni 20. Role of sirtuins in liver diseasesD. Ezhilarasan and M. Najimi 22. Vitagenes in avian biology: protective functions of sirtuinsPeter F. Surai, Ivan I. Kochish, and Vladimir I. Fisinin 23. Sirtuins in hematopoiesis and blood malignanciesBerta N. Vazquez, Irene Fernández-Duran, and Alejandro Vaquero Index
