Description
Sirtuin Biology in Cancer and Metabolic Disease: Cellular Pathways for Clinical Discovery offers a compelling and thought-provoking perspective for the examination of the intriguing biology of sirtuins that ties cancer and metabolic disease together and provides a critical platform for the development of sirtuin-based novel therapeutic strategies to effectively treat cancer and metabolic disorders with precision in order to minimize any potentially detrimental clinical outcomes. An exciting prospect for the development of innovative therapeutics for cancer and metabolic disorders involves sirtuins. Sirtuins are histone deacetylases that have an intricate role in the onset and development of cancer and metabolic disease. Implementing a translational medicine format, this innovative reference highlights the ability of sirtuins to oversee critical pathways that involve stem cell maintenance, cellular proliferation, metabolic homeostasis, apoptosis, and autophagy that can impact cellular dysfunction and unchecked cellular growth that can occur during cancer and metabolic disease. Each chapter offers an intuitive perspective of advances on the application of sirtuin pathways for cancer and metabolic disease that will be become a "go-to" resource for a broad audience of scientists, physicians, pharmaceutical industry experts, nutritionists, and students.- Chapters are authored by internationally recognized experts who elucidate the intimate relationship between cancer and metabolic disease that intersects with sirtuin pathways- Presents the basic and clinical role of sirtuins in regard to cancer and metabolic disease- Summarizes the multidiscipline views and publications for this exciting field of sirtuins for the development of new clinical treatments for cancer and metabolic disease- Provides a vital foundation for a broad audience of healthcare providers, scientists, drug developers, and students in both clinical and research settings
Table of Contents
Preface Section I: Sirtuins and metabolic disease 1. Sirtuins in metabolic disease: innovative therapeutic strategies with SIRT1, AMPK, mTOR, and nicotinamideKenneth Maiese2. Sirtuins in metabolic and epigenetic regulation of stem cellsYi Fang and Xiaoling Li 3. Sirtuins and metabolic regulation: food and supplementationSérgio Henrique Sousa Santos, Victor Hugo Dantas Guimarães, Janaina Ribeiro Oliveira, and Luiz Fernando Rezende 4. Sirtuins in diabetes mellitus and diabetic kidney diseaseKultigin Turkmen 5. Sirtuins and mitochondrial dysfunctionJian-Li He, Tian-Shi Wang, and Yi-Ping Wang 6. Sirtuins in immunometabolismHongxiu Yu 7. Mitochondrial sirtuins at the crossroads of energy metabolism and oncogenic transformationMaja Grabacka and Przemyslaw M. Plonka Section II: Sirtuins and cancer 8. Sirtuins and the hallmarks of cancerTalita H.B. Gomig, Tayana S. Jucoski, Erika P. Zambalde, Alexandre L.K. Azevedo, Daniela F. Gradia, and Enilze M.S.F. Ribeiro 9. The bifunctional roles of sirtuins and their therapeutic potential in cancerYeuan Ting Lee, Yi Jer Tan, Pei Yi Mok, Ayappav. Subramaniam, and Chern Ein Oon 10. Sirtuins and next generation hallmarks of cancer: cellular energetics and tumor promoting inflammationRobert Kleszcz and Wanda Baer-Dubowska 11. Sirtuins and cellular metabolism in cancersZhen Dong and Hongjuan Cui 12. Dual role of sirtuins in cancerMargalida Torrens-Mas and Pilar Roca 13. Sirtuin signaling in hematologic malignanciesRyan A. Denu 14. Impacts of sirtuin1 and sirtuin3 on oral carcinogenesisShajedul Islam, Yoshihiro Abiko, Osamu Uehara, Yasuhiro Kuramitsu, and Itsuo Chiba Index
