Description
- Authored by practicing medicinal chemists—melding real-world research experience with basic concepts and up-to-date methods
- Flexible in presentation— the first five chapters provide a conceptual foundation and historical understanding of the field; subsequent chapters explore the application of concepts. Chapters can be assigned in order of instructor preference and desired emphasis
- Presents easy-to-follow tables and descriptions of assays next to their relevance to medicinal chemistry and drug discovery, along with target values—information rarely found all in one place, but is a crucial reference
- Case studies and Journal Club use current literature to apply concepts from the text to real-life examples. They are also suitable for flipped classrooms and self-study
Table of Contents
Chapter 1. Historical perspective and overview of drug discovery Chapter 2. Drug discovery: hit and lead discovery Chapter 3. Drug discovery: optimization of lead properties Chapter 4. Medicinal chemistry strategies used in lead optimization Chapter 5. The process of developing a drug from an optimized lead Chapter 6. Receptors as drug targets Chapter 7. Enzymes as drug targets Chapter 8. Protein-protein interactions and lipids as drug targets Chapter 9. DNA and RNA as drug targets Chapter 10. Anti-cancer drugs Chapter 11. Infectious diseases I: antiviral and antifungal drugs Chapter 12. Infectious diseases II: antibacterial and antiparasitic drugs Chapter 13. Drugs acting on the CNS
