臨床研究のための批判的思考法 Critical Thinking in Clinical Research : Applied Theory and Practice Using Case Studies

著者名：Fregni, Felipe (EDT)/Illigens, Ben M.W. (EDT)

Oxford University Press（2018/03/13発売）

• 言語：ENG
• ISBN：9780199324491
• eISBN：9780199324514

Description

One of the most crucial skills a clinician, scientist, or student can learn is to create, conduct, and interpret the conclusions of a clinical study. Critical Thinking in Clinical Research teaches these fundamentals in four distinct sections, called "units": the first unit focuses on issues surrounding the design of a study such as population, question selection, randomization, and blinding; Unit 2 presents statistical methods such as analyzing data collected, how to present and discuss the data concisely; the third unit covers practical aspects such as methodology, organizational considerations, principles of trial conduct and reporting; and the final unit delves into study designs, providing the advantages and drawbacks of each design style.Each chapter begins with a short introduction, followed by a hypothetical case that challenges the reader to make decisions, to consider pros and cons of specific approaches, and to evaluate options based on specific conditions. Knowing how to critically read and understand scientific papers and to collect, analyze, and interpret research data, which they in turn can then present in their own scientific manuscript makes this book the perfect resource for anyone looking to contribute to the wealth of scientific and medical inquiry.

Table of Contents

Section 1CHAPTER 1: Basics of Clinical Research: Introduction to Clinical ResearchRui Nakamura, Faiza Khawaja, Laura Castillo, Felipe Fregni, Steven FreedmanCHAPTER 2: Selection of the Research QuestionKeiko Ueda and Lotfi B. MerabetCHAPTER 3: Study PopulationSandra Carvalho and Felipe FregniCHAPTER 4: Basic Study DesignsAlexandra Gomez, Felipe Fregni, and Vera NovakCHAPTER 5: RandomizationJuliana C Ferreira, Ben Illigens, and Felipe FregniCHAPTER 6: BlindingRita Tomás and Joseph MassaroCHAPTER 7: Recruitment and AdherenceTimo Siepmann, Ana Isabel Penzlin, and Felipe FregniSection 2CHAPTER 8: Basics of StatisticsClaudia Kimie Suemoto and Catherine LeeCHAPTER 9: Parametric Statistical TestsBen Illigens, Fernanda Lopes, and Felipe FregniCHAPTER 10: Non-parametric Statistical TestsFelipe Fregni and Fernanda LopesCHAPTER 11: Sample Size CalculationMohammad Azfar Qureshi and Jessica PaulusCHAPTER 12: Survival AnalysisJorge Leite and Sandra CarvalhoCHAPTER 13: Other Issues in Statistics I (missing data, intention-to-treat analysis and covariate adjustment)Tamara Jorquiera and Hang LeeCHAPTER 14: Other Issues in Statistics II (Subgroup analysis and meta-analysis)Jorge Leite and Munir BoodhwaniSection 3CHAPTER 15: Non-Inferiority DesignRaquel Ajub Moyses, Valeriam Angelim, and Scott EvansCHAPTER 16: Observational StudiesMinou Djannatian and Clarissa ValimCHAPTER 17: Confounders And Using The Method Of Propensity ScoresChin LinCHAPTER 18: Adaptive Trials and Interim AnalysisPriscila Andrade, Nazem Atassi, and Laura Castillo-SaavedraSection 4CHAPTER 19: Integrity in Research: Authorship & EthicsSandra Carvalho and Gustavo RivaraCHAPTER 20: The Business of Clinical ResearchLívia Caroline, Mariano Compte, and Jorge LeiteCHAPTER 21: Design and Analysis of SurveysAna R. Martinez and Inês C.R. HenriquesCHAPTER 22: Assessing Risk and Adverse EventsLaura Castillo-Saavedra, Suely Matsubayashi, Faiza Khawaja, John Ferguson, and Felipe FregniCHAPTER 23: Manuscript SubmissionAlma Tamara Sanchez Jimenez and Felipe Fregni