Description
Now fully revised, this acclaimed textbook efficiently links basic biochemistry with the day-to-day practice of medicine.You will learn basic science concepts and see them illustrated by clinical cases that describe patients you will likely encounter in your clinical training. You will also learn about the use of laboratory tests to diagnose and monitor the most important conditions.Brought to you in a thorough yet accessible manner, this new edition of Medical Biochemistry highlights the latest developments in regulatory and molecular biology, signal transduction, biochemistry and biomarkers of chronic disease, and bioinformatics and the '–omics'. It highlights the most important global medical issues: diabetes mellitus, obesity and malnutrition, cancer and atherosclerotic cardiovascular disease, and addresses the role of nutrition and exercise in medicine.Featuring a team of expert contributors that includes investigators involved in cutting-edge research as well as experienced clinicians, this book offers a unique combination of research and clinical practice tailored to today's integrated courses.- Read organ-focused chapters addressing the biochemistry of the bone, kidney, liver, lungs and muscle; and system-focused ones addressing the biochemistry of the immune and endocrine systems, neurochemistry and neurotransmission, and cancer- Featuring a team of expert contributors that includes investigators involved in cutting-edge research as well as experienced clinicians, this book offers a unique combination of research and clinical practice tailored to today's integrated courses.- Read organ-focused chapters addressing the biochemistry of the bone, kidney, liver, lungs and muscle; and system-focused ones addressing the biochemistry of the immune and endocrine systems, neurochemistry and neurotransmission, and cancer
Table of Contents
Section 1: IntroductionChapter 1 : IntroductionSection 2: Molecules and CellsChapter 2 : Amino Acids and ProteinsChapter 3 : Carbohydrates and LipidsChapter 4 : Membranes and TransportSection 3: MetabolismChapter 5 : Hemoglobin and oxygen transportChapter 6 : Catalytic Proteins - EnzymesChapter 7 : Vitamins and MineralsChapter 8 : Bioenergetics and Oxidative MetabolismChapter 9 : Anaerobic metabolism of glucose carbohydrates in the red blood cellChapter 10: The Tricarboxylic Acid CycleChapter 11: Oxidative Metabolism of Lipids in Liver and MuscleChapter 12 : Biosynthesis and Storage of Carbohydrates in Liver and MuscleChapter 13: Biosynthesis and Storage of Fatty AcidsChapter 14: Biosynthesis of Cholesterol and SteroidsChapter 15: Biosynthesis and Degradation of Amino AcidsChapter 16: Biosynthesis and Degradation of NucleotidesChapter 17: Complex Carbohydrates: GlycoproteinsChapter 18: Complex LipidsChapter 19: The Extracellular MatrixSection 4: Molecular basis of inheritanceChapter 20: Deoxyribonucleic AcidChapter 21: Ribonucleic AcidChapter 22: Protein Synthesis and TurnoverChapter 23: Regulation of Gene Expression: Basic MechanismsChapter 24: Genomics, Proteomics and MetabolomicsSection 5: Signalling and GrowthChapter 25: Membrane Receptors and Signal TransductionChapter 26: NeurotransmittersChapter 27: Biochemical EndocrinologyChapter 28: Cellular Homeostasis: Cell Growth and CancerChapter 29: AgingSection 6: Fuels Nutrients and MineralsChapter 30: Digestion and Absorption of Nutrients: The Gastrointestinal TractChapter 31: Glucose Homeostasis and Fuel Metabolism: Diabetes MellitusChapter 32: "Nutrients and diets"Chapter 33: Lipoprotein Metabolism and AtherogenesisSection 7: Specialized Tissues and Their FunctionChapter 34: The Role of Liver in MetabolismChapter 35: Water and Electrolytes HomeostasisChapter 36: Lung and the Regulation of Hydrogen Ion Concentration (Acid-Base Balance)Chapter 37: Muscle: Energy Metabolism and Contraction ExerciseChapter 38: Bone Metabolism and Calcium HomeostasisChapter 39: NeurochemistrySection 8: Blood and Immunity. Clinical BiochemistryChapter 40: Blood and Plasma ProteinsChapter 41: Haemostasis and ThrombosisChapter 42: Oxidative stress and inflammationChapter 43: The Immune Response: Innate and adaptive immunityAppendix 1: Selected Clinical laboratory reference rangesAppendix 2: Case Studies
