Description
Now fully revised, this acclaimed textbook efficiently links basic biochemistry with the day-to-day practice of medicine. You will learn basic science concepts and see them illustrated by clinical cases that describe patients you will likely encounter in your clinical training. You will also learn about the use of laboratory tests to diagnose and monitor the most important conditions. Brought to you in a thorough yet accessible manner, this new edition of Medical Biochemistry, Fifth Edition highlights the latest developments in regulatory and molecular biology, signal transduction, biochemistry and biomarkers of chronic disease, and bioinformatics and the '-omics'. It highlights the most important global medical issues: diabetes mellitus, obesity and malnutrition, cancer and atherosclerotic cardiovascular disease, and addresses the role of nutrition and exercise in medicine.- Featuring a team of expert contributors that includes investigators involved in cutting-edge research as well as experienced clinicians, this book offers a unique combination of research and clinical practice tailored to today's integrated courses- Read organ-focused chapters addressing the biochemistry of the bone, kidney, liver, lungs and muscle; and system-focused ones addressing the biochemistry of the immune and endocrine systems, neurochemistry and neurotransmission, and cancer
Table of Contents
Section 1: Introduction1. IntroductionSection 2: Molecules and Cells2. Amino Acids and Proteins3. Carbohydrates and Lipids4. Membranes and TransportSection 3: Metabolism5. Hemoglobin and oxygen transport6. Catalytic Proteins - Enzymes7. Vitamins and Minerals8. Bioenergetics and Oxidative Metabolism9. Anaerobic metabolism of glucose carbohydrates in the red blood cell10. The Tricarboxylic Acid Cycle11. Oxidative Metabolism of Lipids in Liver and Muscle12. Biosynthesis and Storage of Carbohydrates in Liver and Muscle13. Biosynthesis and Storage of Fatty Acids14. Biosynthesis of Cholesterol and Steroids15. Biosynthesis and Degradation of Amino Acids16. Biosynthesis and Degradation of Nucleotides17. Complex Carbohydrates: Glycoproteins18. Complex Lipids19. The Extracellular MatrixSection 4: Molecular Basis of Inheritance20. Deoxyribonucleic Acid21. Ribonucleic Acid22. Protein Synthesis and Turnover23. Regulation of Gene Expression: Basic Mechanisms24. Genomics, Proteomics and MetabolomicsSection 5: Signalling and Growth25. Membrane Receptors and Signal Transduction26. Neurotransmitters27. Biochemical Endocrinology28. Cellular Homeostasis: Cell Growth and Cancer29. AgingSection 6: Fuels Nutrients and Minerals30. Digestion and Absorption of Nutrients: The Gastrointestinal Tract31. Glucose Homeostasis and Fuel Metabolism: Diabetes Mellitus32. Nutrients and diets33. Lipoprotein Metabolism and AtherogenesisSection 7: Specialized Tissues and Their Function34. The Role of Liver in Metabolism35. Water and Electrolytes Homeostasis36. Lung and the Regulation of Hydrogen Ion Concentration (Acid-Base Balance)37. Muscle: Energy Metabolism and Contraction Exercise38. Bone Metabolism and Calcium Homeostasis39. NeurochemistrySection 8: Blood and Immunity. Clinical Biochemistry40. Blood and Plasma Proteins41. Haemostasis and Thrombosis42. Oxidative stress and inflammation43. The Immune Response: Innate and adaptive immunityAppendix 1: Selected Clinical laboratory reference rangesAppendix 2: Case Studies
