Description
Reproductive and Developmental Toxicology, Second Edition, is a comprehensive and authoritative resource that provides the latest literature on this complex subject with a primary focus on three core components—parent, placenta, and fetus—and the continuous changes that occur in each. Enriched with relevant references describing every aspect of reproductive toxicology, this revised and updated resource addresses the totality of the subject, discussing a broad range of topics, including nanoparticles and radiation, gases and solvents, smoking, alcohol and drug abuse, and metals, amongst others.
With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages, also including discussions on reproductive and developmental toxicity in domestic animals, fish, and wildlife.
Completely revised and updated to include the most recent developments in the field, the book is an essential resource for advanced students and researchers in toxicology, as well as biologists, pharmacologists, and teratologists from academia, industry, and regulatory agencies.
- Provides a complete, up-to-date, integrated source of information on the key risk stages during reproduction and development
- Includes new chapters covering significant developments, such as dose-response assessment for developmental toxicity, juvenile toxicity, and neural tube defects, as well as emerging science, such as stem cell application, toxicoproteomics, metabolomics, endocrine disruption, surveillance and regulatory considerations, and risk assessment
- Offers diverse and unique in vitro and in vivo toxicity models for reproductive and developmental toxicity testing in a user-friendly format that assists in comparative analysis
Table of Contents
Section I. General1. Introduction2. Reproductive Anatomy and Physiology3. Pharmacokinetics in Pregnancy4. Physiologically Based Pharmacokinetic Models in Reproductive and Developmental Toxicology5. Drugs and Chemical Contaminants in Human Breast Milk
Section II. Toxicity Testing Models and Safety Evaluation6. Reproductive and Developmental Safety Evaluation of New Pharmaceutical Compounds7. Juvenile Toxicology Testing8. Postmarket Surveillance and Regulatory Considerations in Reproductive and Developmental Toxicology: A Food and Drug Administration Perspective9. OECD Guidelines for In Vivo Testing of Reproductive Toxicity10. Guidelines for Reproductive and Developmental Toxicity Testing and Risk Assessment of Chemicals11. Validated and Nonvalidated Mechanism-Based Methods for Testing Developmental Toxicity12. Relevance of Animal Testing and Sensitivity of End Points in Reproductive and Developmental Toxicity13. Embryonic Toxic Lesions and Stem Cell Therapy14. In Vitro and Alternative Approaches to Developmental Neurotoxicity15. In Vitro Biomarkers of Developmental Neurotoxicity16. Using Zebrafish to Assess Developmental Neurotoxicity17. Caenorhabditis elegans as a Model to Assess Reproductive and Developmental Toxicity18. A Primate as an Animal Model for Reproductive and Developmental Toxicology Testing
Section III. Nanoparticles and Radiation19. Developmental Toxicity of Engineered Nanomaterials20. Toxicity of Radiation: Biological Effects of Ionizing Radiation Exposure on Reproduction
Section IV. Gases and Solvents21. Reproductive and Developmental Toxicity of Solvents and Gases
Section V. Drugs of Abuse and Addiction, Smoking and Alcohol22. Caffeine23. Developmental Neurotoxicity of Abused Drugs24. Effects of Alcohol on Embryo/Fetal Development25. Cigarette Smoking and Reproductive and Developmental Toxicity
Section VI. Pharmaceuticals and Food Additives26. Thalidomide27. Retinoids28. Melamine and Cyanuric Acid29. Ionophores
Section VII. Metals30. Boron31. Arsenic, Cadmium, and Lead32. Manganese33. Mercury34. Selenium
Section VIII. Pesticides, Industrial and Other Environmental Contaminants35. Organophosphates and Carbamates36. Chlorinated Hydrocarbons and Pyrethrins/Pyrethroids37. Herbicides and Fungicides38. Brominated Flame Retardants39. Polychlorinated Biphenyls, Polybrominated Biphenyls, Polychlorinated Dibenzo-p-dioxins, and Polychlorinated Dibenzofurans40. Reproductive Toxicity of Polycyclic Aromatic Hydrocarbons41. Toxicity and Risk Assessment of Bisphenol A42. Ethylene Glycol43. Perfluorooctane Sulfonate and Perfluorooctanoic Acid44. Phthalates45. Personal Care Products and Cosmetics
Section IX. Phytotoxicants, Mycotoxins and Zootoxins46. Toxic plants47. Fumonisins48. Aflatoxins, Ochratoxins, and Citrinin49. Zootoxins
Section X. Special Topics50. Systems Toxicology and Predictive Modeling of Male Developmental Toxicity51. Stem Cells in Developmental Toxicity Testing52. Epigenetics in Reproduction and Development53. Mitochondrial Dysfunction in Reproductive and Developmental Toxicity54. Cell Signaling Mechanisms in Developmental Neurotoxicity55. Neuroinflammation and Oxidative Injury in Developmental Neurotoxicity56. Effects of Stress on Reproductive and Developmental Biology57. Disruption of Cholesterol Homeostasis in Developmental Neurotoxicity
Section XI. Endocrine Disruption, Mutagenicity, Carcinogenicity, Infertility and Teratogenicity58. Endocrine Disruption59. Developmental and Reproductive Disorders—Role of Endocrine Disruptors in Testicular Toxicity60. Mutagenicity and Carcinogenicity: Human Reproductive Cancer and Risk Factors61. Environmental Pollutants and Neural Tube Defects62. Teratogenicity63. Micro–Computed Tomography and Volumetric Imaging in Developmental Toxicology
Section XII. Toxicologic Pathology64. Toxicologic Pathology of the Reproductive System
Section XIII. Placental Toxicity65. The Placental Role in Developmental Programming66. Strategies for Investigating Hemochorial Placentation67. The Significance of ABC Transporters in Human Placenta for the Exposure of Fetus to Xenobiotics68. Placental Toxicity69. Placental Pathology
Section XIV. Domestic and Wildlife Species70. Reproductive and Developmental Toxicity in Avian Species71. Endocrine Disruption in Wildlife Species72. Teratogenesis in Livestock
