Description
In Situ Tissue Regeneration: Host Cell Recruitment and Biomaterial Design explores the body's ability to mobilize endogenous stem cells to the site of injury and details the latest strategies developed for inducing and supporting the body's own regenerating capacity. From the perspective of regenerative medicine and tissue engineering, this book describes the mechanism of host cell recruitment, cell sourcing, cellular and molecular roles in cell differentiation, navigational cues and niche signals, and a tissue-specific smart biomaterial system that can be applied to a wide range of therapies. The work is divided into four sections to provide a thorough overview and helpful hints for future discoveries: endogenous cell sources; biochemical and physical cues; smart biomaterial development; and applications.- Explores the body's ability to mobilize endogenous stem cells to the site of injury- Details the latest strategies developed for inducing and supporting the body's own regenerating capacity- Presents smart biomaterials in cell-based tissue engineering applications—from the cell level to applications—in the first unified volume- Features chapter authors and editors who are authorities in this emerging field- Prioritizes a discussion of the future direction of smart biomaterials for in situ tissue regeneration, which will affect an emerging and lucrative industry
Table of Contents
1. Fundamentals of In Situ Tissue RegenerationSang Jin Lee, James J. Yoo and Antony Atala2. Stem Cell HomingMariusz Z. Ratajczak and Ahmed A. Ismail3. Immunology – Host Responses to BiomaterialsJohn D. Jackson4. Foreign Body Reaction and Stem Cell ResponsesAshwin Nair and Liping Tang5. Roles of endogenous growth factors and small peptides in in situ tissue regenerationSuna Kim, Hyun Sook Hong and Youngsook Son6. Small molecules: Controlling cell fate and functionBaisong Lu and Anthony Atala7. Small RNA Delivery for In Situ Tissue RegenerationNaJung Kim, James J. Yoo, Anthony Atala, and Sang Jin Lee8. Micro and Nano Topographical cues guiding biomaterial host responseDeepak M. Kalaskar and Feras Alshomer9. Mechanobiology and Mechanotherapy in Tissue EngineeringRei Ogawa10. A biomimetic strategy to design biomaterials for in situ tissue regenerationJi Hyun Kim and Sang Jin Lee11. Impact of Matrix Dynamic Properties on Stem Cell ViabilityMarc B. Taraban1, Yuqi Li, Katherine A. Joyner, Joseph P. Stains and Yihua B. Yu12. Cell-free Scaffolds for In situ Tissue RegenerationSeung Hun Park, Bo Keun Lee, James Yoo, Sang Jin Lee and Moon Suk Kim13. In Situ Tissue Regeneration: Host Cell Recruitment and Biomaterial DesignT. Konrad Rajab and Harald Ott14. Synovial Joint: In Situ Regeneration of Osteochondral and Fibrocartilaginous Tissues by Homing of Endogenous CellsSolaiman Tarafder and Chang H. Lee15. Bioengineered strategies for tendon regenerationAna I. Gonçalves, Márcia T. Rodrigues, Rui L. Reis and Manuela E. Gomes16. Volumetric Muscle Repair In SituLindsey E. Shapiroa, Ji Hyun Kima, In Kap Ko, Sang Jin Lee, James J. Yoo and Anthony Atalaa17. Mending The Heart Through In Situ Cardiac RegenerationJeremy Choon Meng Teo, Selwa Mokhtar Boularaoui, Noaf Salah Ali AlWahab and Nicolas Christoforou18. Skin Wound Healing – Skin Regeneration with Pharmacological Mobilized Stem CellsZhaoli Sun and George Melville Williams19. In situ renal regenerationHung-Jen Wang, Sang Jin Lee, Anthony Atala and James J. Yoo20. Regulatory Aspects: regulation aspects of cell-free biomaterial implantsNan Zhang, Alexander Baume, Richard Payne, Julie Allickson21. Business Perspective – case study: commercialized cell-free cardiovascular implantAlexander Sheehy, Byron Lambert and Richard Rapoza
