Description
Access the latest information available in the challenging area of HIV/AIDS management with Sande's HIV/AIDS Medicine, 2nd Edition. Authored by a veritable "who's who" of current global experts in the field, this medical reference book will provide you with all the practical, indispensable guidance you'll need to offer your patients the best possible care.- Access reliable, up-to-the-minute guidance that addresses the realities of HIV/AIDS management in your geographical region, thanks to contributions from a global cast of renowned expert clinicians and researchers.- Locate the clinically actionable information you need quickly with an organization that mirrors the current state of the AIDS epidemic and the different needs of Western vs. developing-world patients and clinicians.- Diagnose AIDS manifestations confidently by comparing them to full-color clinical images.- Improve patient outcomes with the latest findings on the management of AIDS as a chronic illness.- Efficiently review essential data through numerous at-a-glance tables.- Get the most relevant information available on pediatric HIV and AIDS issues; anti-retroviral drugs, including integrase inhibitors; and the use of second- and third-line anti-retroviral drugs in resource-poor settings.- Stay current on the latest actionable information, such as using antiretroviral therapy in patients with tuberculosis and drug-resistant tuberculosis; antiretroviral therapy; immune reconstitution inflammatory syndromes (IRIS); and implementation of the HPV vaccine.
Table of Contents
ContentsPreface viiContributors ixAcknowledgments xvSECTION 1: Epidemiology and biology of HIV infection1 The global epidemiology of HIV/AIDS 3Irum Zaidi, Kevin M De Cock2 The origins and diversification of HIV 15Michael Worobey, Guan-Zhu Han3 Molecular biology of HIV: implications for new therapies 25Warner C Greene, B Matija Peterlin, Matthew H Stremlau4 The immune response to HIV 45Clive M Gray, Pamela Gumbi, Lycias Zembe, Mopo Radebe, Bruce Walker5 Viral and host determinants of HIV-1 disease progression 59Danie¨lle van Manen, Ange´lique B van 't Wout, Hanneke Schuitemaker6 Acute HIV infection 77Anthony D Kelleher, David A Cooper7 Biology of HIV-1 transmission 89Julie OverbaughSECTION 2: Prevention, diagnosis, and treatment of HIV infection8 The design of a global HIV vaccine 97Jerome H Kim, Nelson L Michael9 HIV prevention 113Salim S Abdool Karim10 Laboratory testing for HIV infection 123James C Shepherd, Oliver Laeyendecker, Thomas C Quinn11 Overview of antiretroviral therapy 133Susa Coffey, Paul A Volberding12 Development and transmission of HIV drug resistance 155Mark A Wainberg, Gerasimos J Zaharatos13 Pharmacology of antiretroviral drugs 169Concepta Merry, Charles W Flexner14 Complications resulting from antiretroviral therapy for HIV infection 177David Nolan, Simon Mallal, Peter ReissSECTION 3: Diseases associated with HIV infection15 Oral complications of HIV infection 195John S Greenspan, Deborah Greenspan16 Ocular manifestations of AIDS 207James P Dunn17 Global HIV and dermatology 219Toby Maurer, Robert Michelleti18 Gastrointestinal disorders in HIV including diarrhea 237Marie-Louise C Vachon, Douglas T Dieterich19 Primary neurological manifestation of HIV/AIDS 249David B Clifford, Mengesha A Teshome20 Psychiatric barriers and the international AIDS epidemic 257Chiadi U Onyike, Andrew F Angelino,Glenn J Treisman21 Cardiovascular complications of HIV infection 267Rakesh K Mishra22 Endocrine complications of HIV infection 275Steven A Taylor, Carl Grunfeld,Morris Schambelan23 Renal complications of HIV infection 287Jula K Inrig, Lynda A Szczech,Trevor E Gerntholtz, Paul E Klotman24 Pneumocystis pneumonia 297Robert J Blount, J Lucian Davis,Laurence Huang25 Other HIV-related pneumonias 313John G Bartlett26 HIV-associated tuberculosis 325Leyla Azis, Edward C Jones-Lo´pez,Jerrold J Ellner27 Disseminated Mycobacterium avium complex and other atypical mycobacterial infections 349Mark A Jacobson28 Candida in HIV infection 359William G Powderly29 Cryptococcosis and other fungal infections(histoplasmosis and coccidioidomycosis)in HIV-infected patients 369Kathleen R Page, Richard E Chaisson,Merle Sande30 Infection due to Penicillium marneffei 389Thira Sirisanthana, Khuanchai Supparatpinyo31 AIDS-associated toxoplasmosis 397Pablo A Moncada, Jose G Montoya32 Hepatitis virus infections 411Marion G Peters, Monika Sarkar33 Bartonella infections in HIV-infected individuals 421Jane E Koehler34 Management of herpesvirus infections(cytomegalovirus, herpes simplex virus, and varicella-zoster virus) 433W Lawrence Drew, Kim S Erlich35 HIV-associated malignancies 455Ronald T Mitsuyasu36 STDs and syphilis 467Elysia Larson, Jeffrey D KlausnerSECTION 4: Prevention and management37 Prevention of mother-to-child transmission of HIV-1 485Lynne M Mofenson38 Managing HIV infection in children and adolescents 509Elizabeth H Doby, Andrew T Pavia39 Special issues regarding women with HIV infection 521Ruth M Greenblatt, Monica Gandhi40 HIV disease among substance users:treatment issues 537R Douglas Bruce, Frederick L Altice,Gerald Friedland41 The HIV-infected international traveler 551Malcolm JohnIndex 561
