Description
Streptococcus Pneumoniae: Molecular Mechanisms of Host-Pathogen Interactions provides a comprehensive overview of our existing knowledge on Streptococcus pneumoniae antibiotic resistance, dissemination, and pathogenesis, including immunology.It presents a state-of-the-art overview of the implications of existing data, along with the areas of research that are important for future insights into the molecular mechanisms of pneumococcal infections and how to combat these infections.Users will find a timely update on the topic, as the dramatic increase in antibiotic resistance pneumoniae cases and limitations of the currently available pneumoniae vaccines are creating new concerns on these gram-positive bacteria that are endowed with a high virulence potential, and are the most common etiologic agent of respiratory and life-threatening invasive diseases.- Provides an updated overview of our existing knowledge on Streptococcus pneumoniae antibiotic resistance, dissemination, and pathogenesis, including immunology- Helps strengthen interdisciplinary networking and the focus of scientific resources by targeting epidemiology, vaccines, genetics, antibiotic resistance, clonal dissemination, Streptococcus pneumoniae biology, functional genomics, inflammasome, biomarkers, and more- Multi-authored by leaders in the field who present a state-of-the-art overview of what the implications are of existing data, and the areas of research that are important for future insights into the molecular mechanisms of pneumococcal infections- Supports combinatory networking in order to find new solutions in clinical therapies- Reflects the most topical pneumococcal research trends
Table of Contents
Section A: Streptococcus pneumoniae Epidemiology and Vaccines1. Pneumococcal molecular epidemiology 2. Antibiotic resistance of pneuomocci3. Pneumococcal vaccination and consequences4. Protein based vaccinesSection B: Genetics and Functional Genomics of Streptococcus pneumoniae5. Genomics, genetic variation and regions of differences6. Functional Genomics of pneumococci (Transcriptional regulation)7. Pneumococcal genetic recombination during colonization and biofilm formation8. The pneumococcal cell wall9. Capsule structure, synthesis and regulation10. Pneumococcal ABC transporters and their role in physiology and multidrug resistanceSection C: Streptococcus pneumoniae Biology11. Structure and functions of surface protein/choline binding proteins12. Pneumococcal non-adhesive surface proteins 13. Biofilm formation under in vitro conditions14. PneumolysinSection D: Pneumococcal Interactions with the Host15. Nasopharyngeal colonization16. Otitis media and biofilms17. Pneumococcal pili and adhesins18. Exploitation of host signal transduction pathways induced by S. pneuomoniae19. Mechanisms of predisposition to pneumonia: infants, the elderly, and viral infections20. Mechanisms causing the inflammatory response to Streptococcus pneumoniae21. Immune evasion mechanisms of pneumococci22. Cell mediated adaptive immunity to pneumococci23. Pneumococcal invasion
