Description
A valuable study of the science behind the medicine, Muscle: Fundamental Biology and Mechanisms of Disease brings together key leaders in muscle biology. These experts provide state-of-the-art insights into the three forms of muscle--cardiac, skeletal, and smooth--from molecular anatomy, basic physiology, disease mechanisms, and targets of therapy. Commonalities and contrasts among these three tissue types are highlighted. This book focuses primarily on the biology of the myocyte.Individuals active in muscle investigation--as well as those new to the field--will find this work useful, as will students of muscle biology. In the case of hte former, many wish to grasp issues at the margins of their own expertise (e.g. clinical matters at one end; molecular matters at the other), adn this book is designed to assist them. Students, postdoctoral fellows, course directors and other faculty will find this book of interest. Beyond this, many clinicians in training (e.g. cardiology fellows) will benefit.- The only resource to focus on science before the clinical work and therapeutics- Tiered approach to subject: discussion first of normal muscle function through pathological/disease state changes, and ending each section with therapeutic interventions- Coverage of topics ranging from basic physiology to newly discovered molecular mechanisms of muscle diseases for all three muscle types: cardiac, skeletal, and smooth
Table of Contents
Part 1: Introduction1. An Introduction to Muscle2. A History of MusclePart II: Cardiac MuscleSection A: Basic Physiology3. Cardiac Myocyte Specification and Differentiation4. Transcriptional Control of Cardiogenesis5. Cardiomyocyte Ultrastructure6. Overview of CArdiac Muscle Physiology7. Ionic Fluxes and Genesis of the Cardiac Action Potential8. G-Protein-Coupled Receptors in the Heart9. Receptor Tyrosine Kinases in Cardiac Muscle10. Communication in the Heart: Cardiokines as Mediators of a Molecular Social Network11. Calcium Fluxes and Homeostasis12. Excitation-Contraction Coupling in the Heart13. Role of Sarcomeres in Cellular Tension, Shortening, and Signaling in Cardiac Muscle14. Cardiovascular Mechanotransduction15. Cardiomyocyte Metabolism: All Is in Flux16. Transcriptional Control of Striated Muscle Mitochondrial Biogenesis and Function17. Mitochondrial Morphology and Function18. Genetics and Genomics in Cardiovascular Gene Discovery19. Cardiovascular Proteomics: Assessment of Protein Post-Translational ModificationsSection B: Adaptations and Response20. Adaption and Responses: Myocardial Innervations adn Neural Control21. Regulation of Cardiac Systolic Function and Contractility22. Intracellular Signaling Pathways in Cardiac Remodeling23. Oxidative Stress and Cardiac Muscle24. Physiologic and Molecular Responses of the Heart to Chronic Exercise25. Epigenetics in Cardiovascular Biology26. Cardiac MicroRNAs27. Protein Quality Control in Cardiomyocytes28. Cardioprotection29. Cardiac Fibrosis: Cellular and Molecular Determinants30. Autophagy in Cardiac Physiology and Disease31. Programmed Cardiomyocyte Death in Heart Disease32. Wnt and Notch: Potent Regulators of Cardiomyocyte Specification, Proliferation, and DifferentiationSection C: Myocardial Disease33. Congenital Cardiomyopathies34. Genetics of Congenital Heart Disease35. Mechanisms of Stress-Induced Cardiac Hypertrophy36. Ischemic Heart Disease37. The Pathophysiology of Heart Failure38. The Right Ventricle: Reemergence of the Forgotten Ventricle39. Mammalian Myocardial Regeneration40. The Structural Basis of Arrhythmia41. Molecular and Cellular Mechanisms of Cardiac Arrhythmias42. Genetic Mechanisms of Arrhythmia43. Infiltrative adn Protein Misfolding Myocardial Diseases44. Cardiac Aging: From Humans to Molecules45. Adrenergic Receptor Polymorphisms in Heart Failure46. Cardiac Gene Therapy47. Protein Kinases in the Heart: Lessons Learned from Targeted Cancer Therapeutics48. Cell Therapy for Cardiac Disease49. Chemical Genetics of Cardiac Regeneration50. Device Therapy for Systolic Ventricular Failure51. Novel Therapeutic Targets and Strategies against Myocardial DiseasesPart III: Skeletal MuscleSection A: Basic Physiology52. Skeletal Muscle Development53. Skeletal Muscle: Architecture of Membrane Systems54. The Vertebrate Neuromuscular Junction55. Neuromuscular Interactions that Control Muscle Function and Adaptation56. Control of Resting CA2+ Concentration in Skeletal Muscle57. Skeletal Muscle Excitation-Contraction Coupling58. The Contractile Machinery of Skeletal Muscle59. Skeletal Muscle Metabolism60. Skeletal Muscle Fiber TypesSection B: Adaptations and Response61. Regulation of Skeletal Muscle Development and Function by microRNAs62. Musculoskeletal Tissue Injury and Repair: Role of Stem Cells, Their Differentiation, and Paracrine Effects63. Immunological Responses to Muscle Injury64. Skeletal Muscle Adaptation to Exercise65. Skeletal Muscle Regeneration66. Skeletal Muscle Dystrophin-Glycoprotein Complex and Muscular DystrophySection C: Skeletal Muscle Disease67. Statin-Induced Muscle Toxicity: Clinical and Genetic Determinants of Risk68. Myotonic Dystrophy69. Facioscapulohumeral Muscular Dystrophy: Unraveling the Mysteries of a Complex Epigenetic Disease70. ECM-Related Myopathies and Muscular Dystrophies71.
