Description
The development of the cardiovascular system is a rapidly advancing area in biomedical research, now coupled with the burgeoning field of cardiac regenerative medicine. A lucid understanding of these fields is paramount to reducing human cardiovascular diseases of both fetal and adult origin. Significant progress can now be made through a comprehensive investigation of embryonic development and its genetic control circuitry.Heart Development and Regeneration, written by experts in the field, provides essential information on topics ranging from the evolution and lineage origins of the developing cardiovascular system to cardiac regenerative medicine. A reference for clinicians, medical researchers, students, and teachers, this publication offers broad coverage of the most recent advances.Volume One discusses heart evolution, contributing cell lineages; model systems; cardiac growth; morphology and asymmetry; heart patterning; epicardial, vascular, and lymphatic development; and congenital heart diseases.Volume Two includes chapters on transcription factors and transcriptional control circuits in cardiac development and disease; epigenetic modifiers including microRNAs, genome-wide mutagenesis, imaging, and proteomics approaches; and the theory and practice of stem cells and cardiac regeneration.- Authored by world experts in heart development and disease- New research on epigenetic modifiers in cardiac development- Comprehensive coverage of stem cells and prospects for cardiac regeneration- Up-to-date research on transcriptional and proteomic circuits in cardiac disease- Full-color, detailed illustrations
Table of Contents
Volume 11.1 Evolutionary Origins of Hearts1.2 Development and Aging of the Drosophila Heart1.3 Cardiac Development in the Frog1.4 Cardiac Development in the Zebrafish1.5 An Overview of Avian Heart Structure and Development2.1 The Specification of Myocardial Progenitor Cells in the Ciona Tadpole2.2 The Secondary Heart Field2.3 Patterning and Development of the Conduction system of the Heart3.1 The Behaviour of Cells that Form the Myocardial Compartments of the Heart3.2 The Ballooning Model for Formation of Cardiac Chambers3.3 Retinoids and Heart Development3.4 A System for Describing Congenital Cardiac Malformations and Correlating Them With Abnormal Cardiac Development4.1 Cardiac Left-Right Asymmetry4.2 Molecular Mechanisms of Left/Right Development4.3 Pitx2 in Cardiac Left Right Asymmetry and Human Disease5.1 Epicardial Lineage: Origins and Fates5.2 The Epicardial Signaling Center in Development and Disease6.1 Molecular Regulation of Cushion Morphogenesis6.2 Signalling Pathways in Valve Formation: Origins of Congenital Defects7.1 Role of Cardiac Neural Crest Cells in Morphogenesis of the Heart and Great Vessels7.2 Role of Cardiac Neural Crest in the Development of the Caudal Pharyngeal Arches, the Cardiac Outflow and Disease8.1 Origin of the Vertebrate Endothelial Cell Lineage: Ontogeny and Phylogeny8.2 Vascular Development8.3 Arterio-Venous Patterning in the Vascular System8.4 Lymphatic Vascular DevelopmentVolume 21.1 NK-2 Class Homeodomain Proteins: Conserved Regulators of Cardiogenesis1.2 GATA4 in Heart Development and Disease1.3 Serum Response Factor and Cofactors, Roles in Cardiac Development1.4 T-box Factors1.5 Myocyte Enhancer Factor 2 Transcription Factors in Heart Development and Disease2.1 Chromatin Modification and Remodeling in Heart Development2.2 Histone Deacetylases in Cardiovascular Development and Disease2.3 MicroRNA Regulation of Cardiac Development and Disease3.1 Genomic Analysis in the Developing and Diseased Heart3.2 Exploring Congenital Cardiovascular Anomalies with ENU Mutagenesis3.3 Imaging Cardiac Developmental Malformations in the Mouse Embryo3.4 Proteomic Strategies for Cardiac Transcription Factor Identification3.5 Proteomic Analysis of MEF2 Post-Translational Regulation in the Heart4.1 The Evolution of Regeneration4.2 Cardiac Regeneration in the Zebrafish Model System5.1 Detection and Identification of Tissue Stem Cells: Tracking an Elusive Prey5.2 Human Cardiomyocytes from Embryonic Stem Cells: Windows to Human Biology and Elements for Regeneration6.1 Adult Stem Cell-Based Therapy for the Heart6.2 Cell Therapy for Recapitulation of Vascular Network Formation and Functional Heart Muscle Recovery After Myocardial Ischaemia6.3 Cardiac Regeneration and Ageing6.4 Genetic Enhancement of Cardiac Regeneration
