Biomaterials for Spinal Surgery

著者名：Ambrosio, Luigi (EDT)/Tanner, Elizabeth (EDT)

Woodhead Publishing（2012/03/12発売）

• 言語：ENG
• ISBN：9781845699864
• eISBN：9780857096197

Description

There have been important developments in materials and therapies for the treatment of spinal conditions. Biomaterials for spinal surgery summarises this research and how it is being applied for the benefit of patients.After an introduction to the subject, part one reviews fundamental issues such as spinal conditions and their pathologies, spinal loads, modelling and osteobiologic agents in spinal surgery. Part two discusses the use of bone substitutes and artificial intervertebral discs whilst part three covers topics such as the use of injectable biomaterials like calcium phosphate for vertebroplasty and kyphoplasty as well as scoliosis implants. The final part of the book summarises developments in regenerative therapies such as the use of stem cells for intervertebral disc regeneration.With its distinguished editors and international team of contributors, Biomaterials for spinal surgery is a standard reference for both those developing new biomaterials and therapies for spinal surgery and those using them in clinical practice.- Summarises recent developments in materials and therapies for the treatment of spinal conditions and examines how it is being applied for the benefit of patients- Reviews fundamental issues such as spinal conditions and their pathologies, spinal loads, modelling and osteobiologic agents in spinal surgery- Discusses the use of bone substitutes and artificial intervertebral discs and covers topics such as the use of injectable biomaterials like calcium phosphate for vertebroplasty and kyphoplasty

Table of Contents

Contributor contact detailsChapter 1: Introduction to biomaterials for spinal surgeryAbstract:1.1 Introduction1.2 Total disc replacement1.3 Nucleus pulposus replacement1.4 Materials for spinal applications1.5 ConclusionsPart I: Fundamentals of biomaterials for spinal surgeryChapter 2: An overview of the challenges of bringing a medical device for the spine to the marketAbstract:2.1 Introduction2.2 Selection and sourcing of materials in medical device developments2.3 Biocompatibility testing2.4 Medical device regulation2.5 Conclusions2.6 AcknowledgementChapter 3: Introduction to spinal pathologies and clinical problems of the spineAbstract:3.1 Introduction3.2 Degenerative spine disease3.3 Spinal trauma3.4 Spinal deformity3.5 Malignancy3.6 Infection3.7 ConclusionsChapter 4: Forces on the spineAbstract:4.1 Introduction4.2 In vivo measured components of spinal loads4.3 In vitro measured spinal load components4.4 Analytical models for spinal load estimation4.5 Recommendations for the simulations of loads for in vitro and numerical studies4.6 ConclusionsChapter 5: Finite element modelling of the spineAbstract:5.1 Introduction5.2 Functional spine biomechanics and strength of numerical explorations5.3 Geometrical approximations in spine finite element modelling5.4 Numerical approximations: accuracy and computational cost5.5 Constitutive models for the spine tissues5.6 Simulating the mechanical loads on the spine5.7 Model verifications and interpretations: the validation concept and quantitative validation5.8 Future trends and conclusions: the virtual physiological spineChapter 6: Osteobiologic agents in spine surgeryAbstract:6.1 Introduction6.2 Bone formation and healing6.3 Osteobiologics for spine fusion6.4 Bone growth factors6.5 Cellular biologics6.6 ConclusionsPart II: Spinal fusion and intervertebral discsChapter 7: Spine fusion: cages, plates and bone substitutesAbstract:7.1 Introduction7.2 Spine fusion: historical concerns and surgical skills7.3 Bone substitutes in spine fusion7.4 Bone growth factors7.5 Autologous bone marrow7.6 Future trendsChapter 8: Artificial intervertebral discsAbstract:8.1 Introduction8.2 Structure and function of the intervertebral disc8.3 The artificial intervertebral disc: design and materials8.4 Fibre-reinforced composite materials: basic principles8.5 Composite biomimetic artificial intervertebral discs8.6 Future trends and conclusionsChapter 9: Biological response to artificial discsAbstract:9.1 Introduction9.2 The healing response to intervertebral disc implants9.3 Infection as a cause of failure of implants9.4 Loosening and the reaction to the products of wear and corrosion9.5 Carcinogenicity and genotoxicity of metal implants9.6 ConclusionsPart III: Vertebroplasty and scoliosis surgeryChapter 10: The use of polymethyl methacrylate (PMMA) in neurosurgeryAbstract:10.1 Introduction: a history of polymethyl methacrylate (PMMA)10.2 Characteristics of polymethyl methacrylate (PMMA)10.3 Preparation of polymethyl methacrylate (PMMA) for use in clinical practice10.4 Clinical use of polymethyl methacrylate (PMMA) in neurosurgery10.5 Developments in polymethyl methacrylate (PMMA)10.6 ConclusionsChapter 11: Optimising the properties of injectable materials for vertebroplasty and kyphoplastyAbstract:11.1 Introduction11.2 Polymethyl methacrylate (PMMA) based bone cements11.3 Calcium phosphate and calcium sulfate based bone cements11.4 ConclusionsChapter 12: Injectable calcium phosphates for vertebral augmentationAbstract:12.1 Introduction12.2 Polymethyl methacrylate (PMMA)12.3 Calcium phosphate cements12.4 ConclusionsChapter 13: Composite injectable materials for vertebroplastyAbstract:13.1 Introduction: a background on the use of composites in vertebroplasty13.2 Properties of composites for vertebroplasty13.3 Further development in composite injectable materials13.