Antigens, Lymphoid Cells and the Immune Response

著者名：Nossal, G. J. V./Ada, G L/Dixon, F. J. (EDT)/Kunkel, Henry G. (EDT)

Academic Press（2014/06/28発売）

• 言語：ENG
• ISBN：9780125219501
• eISBN：9781483218953

Description

Antigens, Lymphoid Cells, and the Immune Response deals with the nature and properties of antigens and with the functional anatomy and cell physiology of the mammalian lymphoid system which responds to antigens. The book discusses the central questions in cellular immunology; the antigens and the afferent limb of the immune response; and antibodies and the afferent limb of the immune response. The text also describes the organ distribution of antigens; the functional anatomy of the lymphoid system; and the behavior patterns of lymphoid cells. The microscopic and electron microscopic distribution of antigen in lymphoid organs; the interaction of antigens with cells of the reticuloendothelial system; and the interaction of antigen with lymphoid cells are also considered. The book further tackles the role of antigen in immunological tolerance; antibody production and tolerance dissociated; and antigen and lymphoid cells.

Table of Contents

ContentsForeword Preface Acknowledgments 1. Introduction: Central Questions in Cellular Immunology Text 2. Antigens and the Afferent Limb of the Immune Response I. Types of Immunogens A. Artificial and Synthetic Polypeptides B. Fibrous Proteins C. Naturally Occurring Immunogens D. Serum Proteins E. Myoglobin F. Tobacco Mosaic Virus Protein G. Flagella Proteins of SalmoneUa Organisms H. Hemocyanin I. Complex Natural Antigens II. Choice of Immunogen A. Detection of Immunogen by Direct Visualization B. Detection due to Innate Properties C. Detection due to Added Markers D. Detection of Antibody to the Injected Immunogen E. A Perfect Immunogen? III. Summary 3. Antibodies and the Afferent Limb of the Immune Response I. The Structure of Immunoglobulins II. Some Biological Properties of Antibodies A. Cytophilic Properties B. Opsonization C. Follicular Localization of Antigen D. Lymphocyte-Associated Antibodies III. The Influence of Antibodies on the Immune Response IV. Summary 4. Organ Distribution of Antigens I. Reliability of Radioactive Iodide as a Marker for Proteins II. Routes for the Carriage of Substances throughout the Body III. Distribution of Injected Substances throughout the Body A. In Unprimed Animals IV. Influence of Natural Antibody on Antigen Distribution V. Influence of Specific Antibody on Antigen Distribution VI. Influence of Adjuvants on Antigen Distribution VII. Antigen Distribution in Tolerant Animals VIII. Antigen Distribution in Fetal and Young Animals IX. Antigens and the Thymus X. The Distribution of Enantiomorphic Polymers XI. Metabolism of Synthetic Polymers in Responder and Nonresponder Hosts XII. Discussion and Summary 5. The Functional Anatomy of the Lymphoid System I. The Genesis of Lymphocytes A. Fetal Origin B. Bone Marrow as Chief Source of Lymphoid Stem Cells in Adult Life II. Primary Lymphoid Organs A. General Features and Functions B. The Thymus C. The Avian Bursa of Fabricius and Possible Mammalian Analogs III. Peripheral Lymphoid Organs A. General Features and Functions B. Lymph Nodes C. The Spleen D. Peyer's Patches 8 E. Omental "Milky Spots" or Nodes of Ranvier IV. Summary 6. Behavior Patterns of Lymphoid Cells I. Migration Patterns of Lymphoid Cells A. Fate of Marked Lymphocytes B. Thymus-Dependent Lymphocytes C. Thymus-independent Lymphocytes II. Functional Categories of Lymphoid Cells A. Antibody-Forming Cells B. Antigen-Reactive Cells (ARC) C. Other Categories of Function of Lymphocyte III. Heterogeneity among Antibody-Forming and Antigen-Reactive Cells A. Heterogeneity among Antibody-Forming Cells B. Heterogeneity among Antigen-Reactive Cells IV. Summary 7. Microscopic and Electron Microscopic Distribution of Antigen in Lymphoid Organs I. Background Information II. Chief Features of Antigen Capture in the Mammalian Lymphoid System III. Design of Experiments to Study Antigen Action in Vivo IV. Antigen Capture in the Lymph Node Medulla A. Medullary Macrophages B. Anatomical Relationships between Macrophage and Lymphoid Cells C. Antibody-Forming Cells V. Antigen Capture by the Lymph Node Follicle A. General Considerations B. The Antigen-Retaining Dendritic Cells C. Differences between Primary and Secondary Follicles D. Comparison of Different Antigens VI. Special Features of Antigen Capture in the Spleen VII. Antigen Distribution in the Thymus VIII.