Full Description
This book covers all aspects of atherosclerosis from human pathology to experimental studies, from basic science to clinical applications. It comprises 20 chapters including human pathology of human atherosclerosis, cellular biology of atherosclerosis (endothelial cells, smooth muscle cells, monocyte/macrophages, dendritic cells and so on), molecular biology of lipid metabolism and hyperlipidemia, pathophysiology of acute coronary syndrome, plaque vulnerability and plaque rupture, aortic aneurysms, peripheral atherosclerosis. The chapters begin with the history of atherosclerosis followed by different "hypotheses" regarding atherosclerosis. Through these introductions, readers can learn the state-of-the-art information from human pathological observations to basic research, from experimental animal studies to clinical practice. The book includes more than 100 color pictures along with schematic illustrations. An effort has been made to show real pathological observations with clinical implications side by side. This book not only helps researchers and clinicians understand the molecular basis of atherosclerosis, but also guides them to explore the unknown questions based on the experience of the authors. It also serves as a useful reference for medical students interested in learning about cardiovascular diseases or those planning to participate in atherosclerosis research.
Contents
Chapter 1. Atherosclerosis is a Global No.1 Killer.- Chapter 2. Fatty Streaks: Initial (or Precursor) Lesions of Atherosclerosis.- Chapter 3. Atheroma and Its Complicated Lesions.- Chapter 4. Origin of the Foam Cell: The Leading Actor of Inflammation Hypothesis of Atherosclerosis.- Chapter 5. Origin of the Foam Cell: The Leading Actor of Inflammation Hypothesis of Atherosclerosis.- Chapter 6. Cholesterol and Its Carriers - Lipoproteins.- Chapter 7. Foam Cells: Mechanisms of Cholesterol Uptake, Storage, and Extracellular Release, and Their Pathophysiological Significance.- Chapter 8. Cell Death in Atherosclerosis: Apoptosis? or Necrosis? or more?.- Chapter 9. Macrophages as Phagocytes in Atherosclerosis: Heterophagy and Autophagy.- Chapter 10. Vascular Dendritic Cells: Their Roles in Atherosclerosis.- Chapter 11. Vascular Endothelial Cells and Atherosclerosis.- Chapter 12. Development of Initial Lesions and Their Progression to Atheroma.- Chapter 13. The Process of Atheroma Growth, Vulnerability, and Rupture.- Chapter 14. Familial Hypercholesterolemia.- Chapter 15. Cholesterol Embolism.- Chapter 16. Pathology of Acute Coronary Syndromes.- Chapter 17. Aortic Aneurysm and Acute Aortic Syndromes.- Chapter 18. Renovascular Hypertension and Related Conditions.- Chapter 19. Peripheral Arterial Disease of the Lower Extremities.- Chapter 20. Experimental Animal Models for the Study of Atherosclerosis.
