Full Description
This book provides the most updated information of how membrane lipids mediate protein signaling from studies carried out in animal and plant cells. Also, there are some chapters that go beyond and expand these studies of protein-lipid interactions at the structural level. The book begins with a literature review from investigations associated to sphingolipids, followed by studies that describe the role of phosphoinositides in signaling and closing with the function of other key lipids in signaling at the plasma membrane and intracellular organelles.
Contents
Sphingomyelin and its role in cellular signaling.- The driving force of alpha-synuclein insertion and amyloid channel formation in the plasma membrane of neural cells: key role of ganglioside- and cholesterol-binding domains.- The enigmatic role of sulfatides: new insights into cellular functions and mechanisms of protein recognition.- Phosphoinositides and PDZ Domain Scaffolds.- PtdIns(4)P signalling and recognition systems.- PtdIns(4,5)P2-Mediated Cell Signaling: Emerging Principles and PTEN as a Paradigm for Regulatory Mechanism.- Role of Phosphatidylinositol 3,4,5-trisphosphate in Cell Signaling.- The Role of Phosphoinositides and Inositol Phosphates in Plant Cell Signaling.- Phosphatidic Acid-Mediated Signaling.- Phosphatidylserine-mediated cellular signaling.- Cardiolipin-mediated cellular signaling.
